... oculis-related homeobox Six1 - Six6 genes in vertebrates. Six1 , Six2 , Six4 and Six5 are expressed in the muscle lineage. Here, we tested the hypothesis that Six1 and Six4 could participate in the genesis of myogenic stem cells. We show that fewer PAX7+ cells occupy a satellite cell position between...

... ligand/receptor pair EphrinA5/EphA4 has been proposed to repulse MMPs from non-myogenic portions of the limb in chick ( Swartz et al., 2001 ). Future work will identify molecules that directly guide zebrafish MMPs to their destinations. Our findings expand the role of Six1 and Six4 in vertebrate...

...) daughters. We have identified two proteins, Six4 and Groucho (Gro), that link the activity of these two pathways to regulate the earliest cell fate decision in the FSC lineage. Our data indicate that Six4 and Gro promote differentiation towards the polar cell fate by promoting Notch pathway activity...