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Keywords: Six3
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Journal Articles
Journal: Development
Development (2022) 149 (4): dev200035.
Published: 23 February 2022
... reduction in striatal MSNs due to a block in their differentiation. Meis2 directly binds to the Zfp503 and Six3 promoters and is required for their expression and specification of D1 and D2 MSNs, respectively. Finally, Meis2 expression is regulated by Dlx1/2 at least partially through the enhancer hs599...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (14): dev165456.
Published: 23 July 2018
... factor Six3 in a spatially restricted domain of the LGE subventricular zone. Conditional deletion of Six3 also prevents the formation of most D2 MSNs, phenocopying the Sp8/9 mutants. Finally, ChIP-Seq reveals that SP9 directly binds to the promoter and a putative enhancer of Six3 . Thus, this study...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (16): 2969–2981.
Published: 15 August 2017
...-mediated misexpression. Surprisingly, Tc-foxQ2 and Tc-six3 mutually activate each other, forming a novel regulatory module at the top of the aGRN. Comparisons of our results with those of sea urchins and cnidarians suggest that foxQ2 has acquired more upstream functions in the aGRN during protostome...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (23): 4462–4473.
Published: 1 December 2016
... a novel hypomorphic Six3 allele, we demonstrate in mice that variability in Six3 dosage results in different HPE phenotypes. Furthermore, we show that whereas the semilobar phenotype results from severe downregulation of Shh expression in the rostral diencephalon ventral midline, the alobar phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 298–305.
Published: 15 January 2016
... serotonergic neurons that are confined to the apical plate. Development of all neurons has been shown to depend on the function of Six3 . Using a combination of molecular screens and tests of gene function by morpholino-mediated knockdown, we identified SoxC and Brn1/2/4 , which function sequentially...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2614–2624.
Published: 15 July 2012
...Dan Carlin; Diane Sepich; Vandana K. Grover; Michael K. Cooper; Lilianna Solnica-Krezel; Adi Inbal Six3 exerts multiple functions in the development of anterior neural tissue of vertebrate embryos. Whereas complete loss of Six3 function in the mouse results in failure of forebrain formation, its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5291–5300.
Published: 15 December 2011
... and acquire their final characteristics postnatally. The homeobox gene Six3 is expressed in ependymal cells during the formation of the lateral wall of the lateral ventricles in the brain. Here, we show that Six3 is necessary for ependymal cell maturation during postnatal stages of brain development. In its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3613–3623.
Published: 1 September 2011
... interests. © 2011. Wnt TGFβ Nodal BMP Dorsal-ventral axis Anterior-posterior axis Lefty Chordin Six3 FoxQ2 Ciliary band Apical organ Ectoderm patterning Neural development Neural patterning Rapid progress has been made in the last five years...
Journal Articles
Journal: Development
Development (2009) 136 (22): 3791–3800.
Published: 15 November 2009
... these are genes that encode the secreted growth factor Sonic hedgehog (Shh)and the transcription factors Six3 and Zic2. In the mouse, Six3 and Shh activate each other's transcription, but a role for Zic2 in this interaction has not been tested. We demonstrate that in zebrafish, as in mouse, Hh signaling activates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 441–450.
Published: 1 February 2008
...Alfonso Lavado; Oleg V. Lagutin; Guillermo Oliver The homeobox gene Six3 represses Wnt1 transcription. It is also required in the anterior neural plate for the development of the mammalian rostral forebrain. We have now determined that at the 15- to 17-somite stage, the prospective diencephalon...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2401–2413.
Published: 15 May 2005
...Gaia Gestri; Matthias Carl; Irene Appolloni; Stephen W. Wilson; Giuseppina Barsacchi; Massimiliano Andreazzoli Although it is well established that Six3 is a crucial regulator of vertebrate eye and forebrain development, it is unknown whether this homeodomain protein has a role in the initial...
Journal Articles
Journal: Development
Development (2005) 132 (8): 1785–1793.
Published: 15 April 2005
..., neurons located at the ventral midbrain-forebrain border (MFB) give rise to the medial longitudinal fascicle(mlf) and the posterior commissure (pc). We demonstrate that the homeobox genes Sax1, Six3, Emx2 and Pax6 are expressed in distinct domains in this area, suggesting that the specification of mlf...
Journal Articles
Journal: Development
Development (2003) 130 (21): 5155–5167.
Published: 1 November 2003
...Michael E. Zuber; Gaia Gestri; Andrea S. Viczian; Giuseppina Barsacchi; William A. Harris Several eye-field transcription factors (EFTFs) are expressed in the anterior region of the vertebrate neural plate and are essential for eye formation. The Xenopus EFTFs ET, Rx1, Pax6, Six3, Lhx2, tll...
Journal Articles
Journal: Development
Development (2002) 129 (17): 4057–4063.
Published: 1 September 2002
... genes have been identified that, when over-expressed, can initiate ectopic eye formation. Of note is Six3 , which is expressed exclusively in the anterior neural plate. However, ‘loss of function’ analysis has not been reported. Using medaka fish, we show that vertebrate Six3 is necessary for patterning...
Journal Articles
Journal: Development
Development (2002) 129 (12): 2835–2849.
Published: 15 June 2002
...Changqi C. Zhu; Michael A. Dyer; Masanori Uchikawa; Hisato Kondoh; Oleg V. Lagutin; Guillermo Oliver Recent findings suggest that Six3, a member of the evolutionarily conserved So/Six homeodomain family, plays an important role in vertebrate visual system development. However, little is known about...