... human erythropoiesis in vitro . GATA SIX1 SIX2 Retinal determination gene network PAX-SIX-EYA-DACH network Hematopoiesis National Institutes of Health DK072229 Maryland Stem Cell Research Fund 10.13039/100012443 2016-MSCRFE-2753 Mark Foundation for Cancer...

... Six2 Mouse National Institutes of Health 10.13039/100000002 R01 DK100315 Cincinnati Children's Hospital Medical Center 10.13039/100007172 In mammals, nephrons are formed only during development ( McMahon, 2016 ). At the cortex of the developing kidney, mesenchymal...

..., Notch signaling promotes the formation of proximal tubules and represses the formation of distal tubules. Here, we present a novel role of Notch in nephrogenesis. We show in mice that differentiation of nephron progenitors requires downregulation of Six2, a transcription factor required for progenitor...

...Jingyue Xu; Han Liu; Joo-Seop Park; Yu Lan; Rulang Jiang Mammalian kidney organogenesis involves reciprocal epithelial-mesenchymal interactions that drive iterative cycles of nephron formation. Recent studies have demonstrated that the Six2 transcription factor acts cell autonomously to maintain...

..., at least in part, on the activity of the transcription factor Six2. Six2-positive cells that receive the Wnt9b signal are maintained as progenitors whereas cells with reduced levels of Six2 are induced to differentiate by Wnt9b. Using this simple mechanism, the kidney is able to balance progenitor cell...

... the positional information encoded by Hox genes is translated into morphogenetic changes. Here, we conclusively demonstrate that Six2 is a direct downstream target of Hoxa2 in vivo and show that the ectopic expression of Six2 , observed in the absence of Hoxa2, contributes to the Hoxa2 mouse mutant phenotype. We...

... branchial arch derivatives is unclear. We show that Six2, another transcription factor, is genetically downstream of Hoxa2. High levels of Six2 are observed in the Hoxa2 loss-of-function mutant. By using a transgenic approach to overexpress Six2 in the embryonic area controlled by Hoxa2 , we observed...

...Pin-Xian Xu; Weiming Zheng; Li Huang; Pascal Maire; Christine Laclef; Derek Silvius The murine Six gene family, homologous to Drosophila sine oculis ( so ) which encodes a homeodomain transcription factor, is composed of six members ( Six1-6 ). Among the six members, only the Six2 gene has been...