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Keywords: Sinoatrial node
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Journal Articles

Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice

Hua Li, Dainan Li, Yuzhi Wang, Zhen Huang, Jue Xu, Tianfang Yang, Linyan Wang, Qinghuang Tang, Chen-Leng Cai, Hai Huang, Yanding Zhang, YiPing Chen
Journal: Development
Development (2019) 146 (14): dev178145.
https://doi.org/10.1242/dev.178145
Published: 25 July 2019
...Hua Li; Dainan Li; Yuzhi Wang; Zhen Huang; Jue Xu; Tianfang Yang; Linyan Wang; Qinghuang Tang; Chen-Leng Cai; Hai Huang; Yanding Zhang; YiPing Chen ABSTRACT The sinoatrial node (SAN), the primary cardiac pacemaker, consists of a head domain and a junction/tail domain that exhibit different...
View article titled, Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the <span class="search-highlight">sinoatrial</span> <span class="search-highlight">node</span> in mice
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Includes: Supplementary data
Journal Articles

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

Vincent W. W. van Eif, Sonia Stefanovic, Karel van Duijvenboden, Martijn Bakker, Vincent Wakker, Corrie de Gier-de Vries, Stéphane Zaffran, Arie O. Verkerk, Bas J. Boukens, Vincent M. Christoffels
Journal: Development
Development (2019) 146 (8): dev173161.
https://doi.org/10.1242/dev.173161
Published: 25 April 2019
... of the sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3 + pacemaker cells. Here, we have isolated and characterized the Tbx3 + cells from Tbx3 +/Venus knock-in mice. We studied electrophysiological parameters during development and found that Venus-labeled cells are genuine...
View article titled, Transcriptome analysis of mouse and human <span class="search-highlight">sinoatrial</span> <span class="search-highlight">node</span> cells reveals a conserved genetic program
Open the PDF for Transcriptome analysis of mouse and human <span class="search-highlight">sinoatrial</span> <span class="search-highlight">node</span> cells reveals a conserved genetic program in another window
Includes: Supplementary data
Journal Articles

A common Shox2 – Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

Wenduo Ye, Jun Wang, Yingnan Song, Diankun Yu, Cheng Sun, Chao Liu, Fading Chen, Yanding Zhang, Fen Wang, Richard P. Harvey, Laura Schrader, James F. Martin, YiPing Chen
Journal: Development
Development (2015) 142 (14): 2521–2532.
https://doi.org/10.1242/dev.120220
Published: 15 July 2015
... (PV) and systemic venous return. The genetic programs that abnormally reinforce pacemaker properties at these sites and how this relates to normal sinoatrial node (SAN) development remain uncharacterized. It was noted previously that Nkx2-5 , which is expressed in the PV myocardium and reinforces...
View article titled, A common Shox2 – Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and <span class="search-highlight">sinoatrial</span> <span class="search-highlight">node</span>
Open the PDF for A common Shox2 – Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and <span class="search-highlight">sinoatrial</span> <span class="search-highlight">node</span> in another window
Includes: Supplementary data