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Keywords: Single-cell RNA-sequencing
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Journal Articles

Skeletal stem cell fate defects caused by Pdgfrb activating mutation

In collection:
Musculoskeletal system , Stem cells & regeneration
Hae Ryong Kwon, Jang H. Kim, John P. Woods, Lorin E. Olson
Journal: Development
Development (2021) 148 (23): dev199607.
DOI: https://doi.org/10.1242/dev.199607
Published: 02 December 2021
... syndrome Single-cell RNA-sequencing Osteogenesis Chondrogenesis Osteopenia Mouse National Institutes of Health http://dx.doi.org/10.13039/100000002 National Heart, Lung, and Blood Institute http://dx.doi.org/10.13039/100000050 National Institutes of Health http...
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Journal Articles

The molecular and phenotypic makeup of fetal human skin T lymphocytes

In collection:
Human development
René Reitermaier, Tanya Ayub, Julia Staller, Philip Kienzl, Nikolaus Fortelny, Pablo Augusto Vieyra-Garcia, Christof Worda, Christian Fiala, Clement Staud, Wolfgang Eppel, Anke Scharrer, Thomas Krausgruber, Adelheid Elbe-Bürger
Journal: Development
Development (2022) 149 (8): dev199781.
DOI: https://doi.org/10.1242/dev.199781
Published: 26 October 2021
... and immunity. T cells TCR Skin Human Fetal Single-cell RNA-sequencing Flow cytometry Confocal microscopy Austrian Science Fund http://dx.doi.org/10.13039/501100002428 P31485-B30 M2403 Oesterreichische Nationalbank http://dx.doi.org/10.13039/501100004061 16905...
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Stromal androgen and hedgehog signaling regulates stem cell niches in pubertal prostate development

Adam W. Olson, Vien Le, Jinhui Wang, Alex Hiroto, Won Kyung Kim, Dong-Hoon Lee, Joseph Aldahl, Xiwei Wu, Minhyung Kim, Gerald R. Cunha, Sungyong You, Zijie Sun
Journal: Development
Development (2021) 148 (19): dev199738.
DOI: https://doi.org/10.1242/dev.199738
Published: 23 September 2021
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Journal Articles

Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors

Sergi Sayols, Jakub Klassek, Clara Werner, Stefanie Möckel, Sandra Ritz, Maria Mendez-Lago, Natalia Soshnikova
Journal: Development
Development (2020) 147 (18): dev188839.
DOI: https://doi.org/10.1242/dev.188839
Published: 15 September 2020
...Sergi Sayols; Jakub Klassek; Clara Werner; Stefanie Möckel; Sandra Ritz; Maria Mendez-Lago; Natalia Soshnikova ABSTRACT The identity of embryonic gastric epithelial progenitors is unknown. We used single-cell RNA-sequencing, genetic lineage tracing and organoid assays to assess whether Axin2...
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Journal Articles

Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression

Alexander M. Tsankov, Marc H. Wadsworth, II, Veronika Akopian, Jocelyn Charlton, Samuel J. Allon, Aleksandra Arczewska, Benjamin E. Mead, Riley S. Drake, Zachary D. Smith, Tarjei S. Mikkelsen, Alex K. Shalek, Alexander Meissner
Journal: Development
Development (2019) 146 (19): dev174722.
DOI: https://doi.org/10.1242/dev.174722
Published: 12 September 2019
... methylation levels in the de novo knockouts. Furthermore, we found unexpected transcriptional repression upon either loss of the de novo methyltransferase DNMT3A or the double knockout of DNMT3A/3B that is further propagated upon differentiation to mesoderm and ectoderm. Taken together, our single-cell RNA...
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Includes: Supplementary data