... to the native tissue. Hair cells Hearing loss Human inner ear organoids Otic Single-cell RNA-seq Ministerio de Ciencia, Innovación y Universidades PRE2021-097774 PID2020-117662GB-I00 Agencia Estatal de Investigación The inner ear is a sensory organ required...

... sequencing in the large yellow croaker provides insights into the development of spermatogonial stem cells, potentially impacting further conservation and culture of spermatogonial stem cells in teleosts. Seasonal spermatogenesis Single-cell RNA-seq Spermatogonial stem cells Large yellow croaker...

... theory of dynamical systems and high-dimensional transcriptomic data of differentiating cells by studying statistical signatures of linear instability, encoded in a time-varying covariance matrix. Differentiation Bifurcation Single-cell RNA-seq Pseudotime Waddington National Science...

... Summary: Single-cell genomic approaches reveal transcriptomic atlases of midfacial primordia, and a mesenchymal gene regulatory network modulated by Wls during midline facial formation and fusion. Wnt Pax Frontonasal hypoplasia Midline facial clefts Single-cell RNA-seq Gene regulatory network...

... developing pancreas have not been examined. To address this knowledge gap, we performed PDX1 ChIP-seq and single-cell RNA-seq using fetal human pancreata. We integrated our datasets with published datasets and revealed the dynamics of PDX1 binding and potential cell lineage-specific PDX1-bound genes...

.... Takeda Science Foundation http://dx.doi.org/10.13039/100007449 Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691 19H04002 20K15695 Cellular senescence Intermuscular adipose tissue PDGFRα + mesenchymal progenitors Sarcopenia Single-cell RNA...

... . 10.1038/s41467-018-07771-0 Chen , G. , Ning , B. and Shi , T. ( 2019 ). Single-cell RNA-Seq technologies and related computational data analysis . Front. Genet.   10 , 317 . 10.3389/fgene.2019.00317 Chera , S. , Baronnier , D. , Ghila , L. , Cigliola , V...

... et al., 2018 ; Plasschaert et al., 2018 ; Vieira Braga et al., 2019 ), providing a first panorama of human airway cell diversity and lineages that we are extending here, after analyzing single-cell RNA-seq data in fresh human airway epithelial tissues and throughout an experiment in 3D in vitro...

... position and new candidate genes for circuit formation with special emphasis on ipsilaterally projecting RGCs. Neurogenesis Retinal development Single-cell RNA-seq Retinal ganglion cell Axon guidance Cell-fate specification Mouse Understanding how diverse neuronal cell types emerge...

... transcription factors and the establishment of primed and active enhancers. Deletion of Jmjd3 , a histone demethylase for H3K27me3, at the pancreatic progenitor stage impaired the efficiency of endocrine cell fate transition and thereafter islet formation. Curiously, single-cell RNA-seq revealed...