... availability The raw and processed single-cell RNA-sequencing datasets are available in the Gene Expression Omnibus (GEO) database under accession number GSE275013 . © 2025. Published by The Company of Biologists 2025 This is an Open Access article distributed under the terms of the Creative Commons...

... development Ectodermal organs Patterning Cell atlas Gene regulatory networks Single cell RNA-sequencing National Institute of Dental and Craniofacial Research http://dx.doi.org/10.13039/100000072 R90DE031531 R00DE025874 R03DE030205 University of California, Los Angeles http...

... mechanisms downstream of this signaling pathway remain elusive. A number of efforts aimed at understanding the mechanisms of atrial/ventricular lineage segregation have performed bulk and single cell RNA-sequencing (scRNA-seq) as early as embryonic day (E) 9 ( DeLaughter et al., 2016 ; Li et al., 2016...

...-related genes and confirmed with single-cell RNA-sequencing that these changes occur in supporting cells. In situ hybridization was used to further validate these findings. We determined that the JAK/STAT signaling pathway is essential for upregulation of the damage-response genes in supporting cells...

... is known about the processes controlling human CTB progenitor maintenance and differentiation. To address this, we established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify cell states important in trophoblast progenitor establishment, renewal...