...-ventrally defined spatial domains and/or specific sub-populations defined by single cell RNA-seq. Our analysis reveals significant dynamic changes in signalling over the CS13-CS17 period, potentially underpinning gradual maturation of HSCs and progenitors in the human AGM region. Haematopoietic stem...

... diversification of synovial joint constituents. To address this, we have performed single cell RNA-Seq analysis of 7329 synovial joint progenitor cells from the developing murine knee joint from E12.5 to E15.5. By using a combination of computational analytics, in situ hybridization and in vitro characterization...

... with age. Here, we use time-lapse imaging and single cell RNA-seq to measure activation trajectories and rates in young and aged MuSCs. We find that the activation trajectory is conserved in aged cells, and we develop effective machine-learning classifiers for cell age. Using cell-behavior analysis and RNA...

.../ Highlighted Article: Differences in miRNA expression in Müller glia and retinal progenitor cells account for the dissimilarities in their neurogenic potential. Such differences could be manipulated to reprogram MG for retinal regeneration. Retina Reprogramming miRNAs Single cell RNA-seq Ascl1...

... Single cell RNA-seq National Institute of Allergy and Infectious Diseases 10.13039/100000060 R01-AI143290 In 1665, Robert Hooke coined the term ‘cell’ to describe the micro unit of biological tissues ( Hooke, 1665 ). Continued efforts on cells culminated in ‘cell theory...

... specification, this study characterizes all deviations in cell composition, cellular state and differentiation trajectories. Pitx2 Left-right asymmetry Single cell RNA-seq Cardiac development National Institutes of Health 10.13039/100000002 DE023177 HL127717 HL130804 HL118761...

.... Kidney development Single cell RNA-seq Organogenesis Nephron progenitor Ureteric epithelium Murdoch Children's Research Institute State Government of Victoria 10.13039/501100004752 University of Melbourne 10.13039/501100001782 Australian Research Council...

... cells Single cell RNA-seq Muscle regeneration Mouse National Institute of Arthritis and Musculoskeletal and Skin Diseases 10.13039/100000069 AR041126 AR041164 Growth and homeostasis of the skeletal muscle system, a tissue/organ constituting approximately 35% of the human total...