... ( hth )- eyes absent ( eya ) -sine oculis ( so ) -dachshund ( dac ) gene regulatory cassette is involved in this specification. Lamina neurons differentiate from NE progenitors that express hth , eya and so . One of the first events in the differentiation of lamina neurons is the upregulation of dac...

... proceeds ( Fig. 3A ). * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 5 10 2012 © 2013. Published by The Company of Biologists Ltd Eyes absent Sine oculis Eye Head capsule...

...Abigail M. Anderson; Bonnie M. Weasner; Brandon P. Weasner; Justin P. Kumar The SIX family of homeodomain-containing DNA-binding proteins play crucial roles in both Drosophila and vertebrate retinal specification. In flies, three such family members exist, but only two, Sine oculis (So) and Optix...

...Tobias Pauli; Makiko Seimiya; Jorge Blanco; Walter J. Gehring In Drosophila , the sine oculis ( so ) gene is important for the development of the entire visual system, including Bolwig's organ, compound eyes and ocelli. Together with twin of eyeless , eyeless , eyes absent and dachshund , so...

...-antennal disc that will become retina. We show that Wingless signalling establishes the border between the retina and adjacent head structures by inhibiting the expression of the eye specification genes eyes absent, sine oculis and dachshund . Ectopic Wingless signalling leads to the repression...

.... Neither Atonal expression nor Bolwig’s organ formation occurred in the absence of hedgehog, eyes absent or sine oculis activity. Genetic and histochemical analyses indicated that (1) responsible Hedgehog signals derive from the ocular segment, (2) Eyes absent and Sine oculis act downstream...

... master control gene for eye morphogenesis. To determine the extent of evolutionary conservation of the eye morphogenetic pathway, we have begun to identify subordinate target genes of Pax-6 . Previously we have shown that expression of two genes, sine oculis ( so ) and eyes absent ( eya ), is induced...

...Makoto Kobayashi; Reiko Toyama; Hiroyuki Takeda; Igor B. Dawid; Kiyoshi Kawakami ABSTRACT The Drosophila homeobox gene sine oculis is expressed in the rostral region of the embryo in early development and is essential for eye and brain formation. Its murine homolog, Six3 , is expressed...

... oculis and eyes absent as two mediators of the eye-inducing activity of eyeless . We show that eyeless induces and requires the expression of both genes independently during extra eye development. During normal eye development, eyeless is expressed earlier than and is required for the expression of sine...

...Guillermo Oliver; Alvaro Mailhos; Roland Wehr; Neal G. Copeland; Nancy A. Jenkins; Peter Gruss ABSTRACT The Drosophila sine oculis homeobox-containing gene is known to play an essential role in controlling the initial events of pattern formation in the eye disc and is also required...