... throughout all stages of curvature was single-minded 2 ( sim2 ), a Down Syndrome-related transcription factor and homolog of a Drosophila gene ( sim ) required for LR asymmetric looping of the fly gut. We demonstrate that sim2 functions downstream of LR patterning cues to regulate key cellular properties...

...-cell-autonomous regulatory pathways must tightly control MyoD expression to ensure correct initiation of the muscle program at different places in the embryo and at different developmental times. In the present study, we have addressed the involvement of Sim2 (single-minded 2) in limb embryonic...

.... The bHLH-PAS transcription factors SIM1 and SIM2 are co-expressed in the developing MB. We have found that MB neurons are generated and that they survive at least until E18.5 in embryos lacking both Sim1 and Sim2 ( Sim1 -/- ; Sim2 -/- ). However, the MTT and MTEG are histologically absent in Sim1 -/- ;Sim2...

... with the expression of Sim2. Sim2 encodes a basic helix-loop-helix (bHLH-PAS) PAS domain containing transcriptional regulator whose Drosophila homolog, single-minded , is a master regulator of ventral midline development. Both vertebrate and invertebrate Sim family members were found sufficient for the activation...