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Keywords: Silencer
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Journal Articles

A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud

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Qiang Li, Jordan P. Lewandowski, Marian B. Powell, Jacqueline L. Norrie, Seung Hee Cho, Steven A. Vokes
Journal: Development
Development (2014) 141 (9): 1906–1914.
https://doi.org/10.1242/dev.104299
Published: 1 May 2014
... an enhancer and a silencer. The enhancer activity requires sustained Hh signaling. As a Gli-dependent silencer, GRE1 prevents ectopic transcription of Grem1 driven through additional CRMs. In doing so, GRE1 works with additional GREs to robustly regulate Grem1 . We suggest that multiple Gli CRMs may...
View articletitled, A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud
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Includes: Supplementary data
Journal Articles

A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene

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Justin F-X. Ainscough, Rosalind M. John,, Sheila C. Barton, M. Azim Surani
Journal: Development
Development (2000) 127 (18): 3923–3930.
https://doi.org/10.1242/dev.127.18.3923
Published: 15 September 2000
... of the Igf2 gene . Nature 405 , 482 – 485 . 10.1038/35013100 Brenton , J. D. , Drewell , R. A. , Viville , S. , Hilton , K. J. , Barton , S. C. , Ainscough , J. F-X. and Surani , M. A. (1999). A silencer element identified in Drosophila is required...
View articletitled, A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
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Journal Articles

Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch

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Robert A. Drewell, James D. Brenton, Justin F.-X. Ainscough, Sheila C. Barton, Kathy J. Hilton, Katharine L. Arney, Luisa Dandolo, M. Azim Surani
Journal: Development
Development (2000) 127 (16): 3419–3428.
https://doi.org/10.1242/dev.127.16.3419
Published: 15 August 2000
...Robert A. Drewell; James D. Brenton; Justin F.-X. Ainscough; Sheila C. Barton; Kathy J. Hilton; Katharine L. Arney; Luisa Dandolo; M. Azim Surani ABSTRACT The H19 imprinted gene is silenced when paternally inherited and active only when inherited maternally. This is thought to involve a cis -acting...
View articletitled, Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch
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Journal Articles

Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element

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Lei Feng, Nathaniel Heintz
Journal: Development
Development (1995) 121 (6): 1719–1730.
https://doi.org/10.1242/dev.121.6.1719
Published: 1 June 1995
... and notochord. Finally, a transcriptional silencer is required for proper suppression of BLBP transcription at the correct time in non-radial glials of the dorsal spinal cord. The identification of separable transcriptional control elements that program BLBP transcription in vivo suggests that the dynamic...
View articletitled, Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element
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