... maturity can be perturbed by genetic and environmental factors that disrupt hepatic identity and function. Developmental signals and fetal genetic programmes are often dysregulated or reactivated, leading to dedifferentiation and disease. Here, we highlight signalling pathways and transcriptional...

.... Development Epigenetic Intestinal stem cell Metabolism Plasticity Signalling pathways Horizon 2020 10.13039/100010661 668,294 Francis Crick Institute 10.13039/100010438 Cancer Research UK 10.13039/501100000289 FC001105 Medical Research Council 10.13039...

... on the specification of local microenvironments. The regulatory network established here identifies common and distinct molecular signatures of limb connective tissue subtypes, provides novel insight into the signalling pathways governing connective tissue specification, and serves as a resource for connective tissue...

.... * Author for correspondence (e-mail: [email protected] ) 10 9 2003 © The Company of Biologists Limited 2003 2003 Microarray Anteroposterior axis Gastrulation Signalling pathways Tdgf1 Nanog Tissue and organ development of vertebrates is tightly regulated by signalling...