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Keywords: Signalling
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Journal Articles
Journal: Development
Development (2021) 148 (14): dev193268.
Published: 19 July 2021
... tissue maintenance, it is the balance between stem cell proliferation and differentiation that coordinates both processes. Upstream signalling regulates this balance to achieve the required outcome at the population level. Both development and homeostasis require tight regulation of stem cells...
Journal Articles
Journal: Development
Development (2021) 148 (10): dev180760.
Published: 27 May 2021
... between development and regeneration of a specific cell type or structure in one animal exist. Here, we use the brittle star Amphiura filiformis to characterise the role of the FGF signalling pathway during skeletal development in embryos and arm regeneration. In both processes, we find ligands expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186395.
Published: 21 December 2020
... al., 2014 ). This elevated circulating Hh is essential for normal survival under starvation conditions, and thus provides a protective function against nutrient shortage by extending the larval growth period. This pioneering work broke away from the established model of morphogen signalling...
Journal Articles
Journal: Development
Development (2020) 147 (17): dev177956.
Published: 11 September 2020
... development ( Saito et al., 2002 ) – differs between forelimbs and hindlimbs (reviewed by Sheeba and Logan, 2017 ). Transgenic mouse studies have implicated Hox4 and Hox5 paralogues, Wnt/β-catenin signalling and RA signalling in regulating forelimb Tbx5 expression via specific regulatory elements located...
Journal Articles
Journal: Development
Development (2020) 147 (5): dev181297.
Published: 02 March 2020
...Chii J. Chan; Takashi Hiiragi ABSTRACT Many developmental processes involve the emergence of intercellular fluid-filled lumina. This process of luminogenesis results in a build up of hydrostatic pressure and signalling molecules in the lumen. However, the potential roles of lumina in cellular...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2019) 146 (10): dev177105.
Published: 17 May 2019
... is coordinated with cell division and/or expansion of cells in outer layers. In Arabidopsis stems, receptor kinases, PXY and ER , genetically interact to coordinate vascular proliferation and organisation via inter-tissue signalling. The contribution of PXY and ER paralogues to stem patterning is not known, nor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev163956.
Published: 29 October 2018
... skeletal muscle development, where it is a master regulator of the transition from embryonic to foetal myogenesis. Recently, Nfix was shown to be involved in adult muscle regeneration and in muscular dystrophies. Here, we have investigated the signalling that regulates Nfix expression, and show that JunB...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev150433.
Published: 23 July 2018
... distinctive transcriptional and signaling programs drive human germ cell lineage specification from pluripotent stem cells . Cell Stem Cell   21 , 517 - 532.e515 . 10.1016/j.stem.2017.09.005 Leopardo , N. P. and Vitullo , A. D. ( 2017 ). Early embryonic development and spatiotemporal...
Journal Articles
Journal: Development
Development (2018) 145 (9): dev156018.
Published: 25 April 2018
... pathway to regulate cell-to-cell communication and signalling at the synapse. Here, we provide an overview of Toll/TLR signalling and discuss how this signalling pathway regulates various aspects of development across species. In Drosophila , Tolls are involved in epithelial cell competition. During...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2810–2823.
Published: 01 August 2017
... states, each identified by distinct factors and controlled by different signals. Both tissues initiate a common transcriptional state but over time impart regional character, with the acquisition of anterior identity dependent on Shh signalling. Using a network inference approach we predict...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1425–1440.
Published: 15 April 2017
... two important endocardial molecules, Serpine1 and Notch, which are implicated in different aspects of endocardial regeneration. Notch signalling regulates developmental gene expression and features of endocardial maturation. Also, Notch manipulation interferes with attenuation of the inflammatory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2482–2493.
Published: 15 July 2016
...Ian John McGough; Jean-Paul Vincent In order to achieve coordinated growth and patterning during development, cells must communicate with one another, sending and receiving signals that regulate their activities. Such developmental signals can be soluble, bound to the extracellular matrix...
Journal Articles
Journal: Development
Development (2013) 140 (10): 2224–2234.
Published: 15 May 2013
... organisation and cell division are integrated via PXY and ER signalling, which together coordinate development of different cell types that are essential for normal stem formation. wox4 mutants have been described with gross morphology that is similar to wild type but have been reported to contain fewer...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 770–779.
Published: 15 February 2013
... ( Tsuwamoto et al., 2008 ). Cell death cuticle Embryo Endosperm Seed development Signalling Seed production in angiosperms requires a tight coordination of the development of the two zygotic products of double fertilization: the embryo and the endosperm. In the model species Arabidopsis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (21): 3591–3601.
Published: 01 November 2010
...Charalampos Rallis; Sheena M. Pinchin; David Ish-Horowicz Integrins act at signalling crossroads, and their interactions with other signal transduction pathways are key to the regulation of normal and pathological cell cytoarchitecture and behaviour. Here, we describe a signalling cascade that acts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (11): 1777–1785.
Published: 01 June 2010
... ganglia are knots of neurons that innervate and relay sensory signals from several visceral organs and the taste buds. Their development was once thought to be independent, in line with their independent functions. However, recent studies indicate that both systems arise from a morphologically distinct...
Journal Articles
Journal: Development
Development (2009) 136 (20): 3405–3412.
Published: 15 October 2009
...Núria Gavaldà; Humberto Gutierrez; Alun M. Davies For a given cell type, particular extracellular signals generate characteristic patterns of activity in intracellular signalling networks that lead to distinctive cell-type specific responses. Here, we report the first known occurrence...
Journal Articles
Journal: Development
Development (2009) 136 (3): 473–481.
Published: 01 February 2009
...Yanlan Mao; Matthew Freeman Adhesion proteins not only control the degree to which cells adhere to each other but are increasingly recognised as regulators of intercellular signalling. Using genetic screening in Drosophila , we have identified Fasciclin 2 (Fas2), the Drosophila orthologue of neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2739–2750.
Published: 01 August 2007
... or IL-13( Fig. 6A,B ). Immunoblotting for pStat6 demonstrated that this signalling pathway is functional in these cells. We also examined the expression of Stat6 targets in KIM-2 cells by QRT-PCR. As shown in Fig. 6C , Gata3 and IL-4Rα are expressed at low levels in untreated cells and are induced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2397–2405.
Published: 01 July 2007
...Odyssé Michos; Alexandre Gonçalves; Javier Lopez-Rios; Eva Tiecke; Florence Naillat; Konstantin Beier; Antonella Galli; Seppo Vainio; Rolf Zeller Antagonists act to restrict and negatively modulate the activity of secreted signals during progression of embryogenesis. In mouse embryos lacking...
Includes: Supplementary data