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Keywords: Signal transduction
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Journal Articles
Journal: Development
Development (2020) 147 (23): dev192351.
Published: 07 December 2020
.../ Summary: Development of lymphovenous and venous valves is dependent upon the RASA1 Ras GTPase-activating protein that facilitates endothelial cell export of the vascular basement protein collagen IV. Lymphovenous valves Signal transduction Vascular biology Venous valves The Ras signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev175703.
Published: 18 March 2020
... and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev176073.
Published: 15 May 2019
.... Cytoneme Exosome Secretion Signal transduction Wnt signalling Wnt trafficking * Author for correspondence ( s.scholpp@exeter.ac.uk ) Competing interests The authors declare no competing or financial interests. © 2019. Published by The Company of Biologists Ltd 2019 The Wnt...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
... signaling pathways ( Fig. 1 B-E). These seemingly straightforward signal transduction cascades impact virtually every developmental process, from cell fate specification to morphogenesis. BMP Cancer TGFβ Signal transduction Summary: This Meeting Review of the 2017 FASEB conference ʻThe...
Journal Articles
Journal: Development
Development (2017) 144 (19): 3612–3624.
Published: 01 October 2017
... in combination with live cell imaging, reveals that the Hedgehog deployment protein Dispatched promotes cytoneme occurrence by slowing retraction rates. Cytoneme Hedgehog Dispatched Morphogen Signal transduction During development, tissue patterning occurs as a consequence of morphogenetic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1841–1850.
Published: 15 May 2017
... disc. Drosophila Signal transduction Hedgehog Smoothened Phosphorylation Fused kinase SNAP-tag labeling The Hedgehog (HH) signaling pathway is crucial for the growth and patterning of many metazoans ( Lee et al., 2016 ). Its deregulation leads to developmental disorders...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3582–3590.
Published: 01 October 2016
... Ltd 2016 Summary: During zebrafish angiogenesis, endothelial PKA activity regulates the transition from sprouting to stabilisation of nascent vessels, preventing excessive tip cell formation and hypersprouting. Notch Angiogenesis Retina Signal transduction Sprouting Vascular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1710–1720.
Published: 15 May 2016
... - 598 . 10.1016/j.celrep.2014.03.020 Summary: In the Drosophila intestine, Tankyrase is important for Wingless signaling activation in enterocytes, thus non-autonomously regulating intestinal stem cell proliferation. Axin Signal Transduction Tankyrase Wingless Wnt β-catenin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 931–942.
Published: 01 March 2015
... and de Sauvage, 2011 ; Amakye et al., 2013 ). Drosophila Hedgehog Signal Transduction Costal 2 (Cos) Fused Summary: Costal 2 must bind Fused for efficient Ci-155 processing and for Fused activation in response to Hedgehog but mapped Fused phosphorylation sites on Costal 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4139–4148.
Published: 01 November 2014
... through plasmodesmata (PD). PD conductivity is regulated by endogenous and exogenous signals. However, the underlying signaling mechanisms remain enigmatic. In Arabidopsis , signal transduction mediated by the receptor-like kinase STRUBBELIG (SUB) contributes to inter-cell layer signaling during tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1705–1714.
Published: 15 April 2014
.... , Ou Z. , Sakakibara K. , Hirahara S. , Iwasaki T. , Sato K. , Fukami Y. ( 2007 ). Characterization of Xenopus egg membrane microdomains containing uroplakin Ib/III complex: roles of their molecular interactions for subcellular localization and signal transduction...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3392–3401.
Published: 15 September 2012
... TGFβ Signal transduction Ecdysone receptor During embryonic development in animals, secreted Transforming Growth Factor β (TGFβ) proteins perform a multitude of tasks. Later in life, mutations that disrupt TGFβ signaling often lead to tumor growth. One group of TGFβ pathway regulators...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 612–621.
Published: 01 February 2012
... for effects on Hh signal transduction. Cysteine mutagenesis reveals that previously uncharacterized functional roles exist for Smo EC1 and EC2. We provide in vitro and in vivo evidence that EC1 cysteine mutation induces significant Hh-independent Smo signaling, triggering a level of pathway activation similar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 843–853.
Published: 01 March 2009
..., MA 01701, USA § Present address: University of South Florida, Tampa, FL 33620, USA 18 12 2008 © 2009. 2009 Integrins Signal transduction Wnt genes Receptor tyrosine kinase Integrins are a major family of heterodimeric transmembrane receptors through which cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 307–316.
Published: 15 January 2009
...Hongge Jia; Yajuan Liu; Wei Yan; Jianhang Jia The seven-transmembrane protein Smoothened (Smo) and Zn-finger transcription factor Ci/Gli are crucial components in Hedgehog (Hh) signal transduction that mediates a variety of processes in animal development. In Drosophila , multiple kinases have been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4025–4035.
Published: 15 December 2008
... aspects of axonal development in vivo. e-mail: julian.ng@kcl.ac.uk 15 10 2008 © 2008. 2008 Neural development Signal transduction Cytoskeleton Drosophila In developing neurons, axon and dendrite extensions are directed by specialised motile structures termed growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3839–3848.
Published: 01 December 2008
...@unr.edu ) 22 9 2008 © 2008. 2008 Drosophila genetics Axon guidance Body patterning Cell migration Central nervous system Signal transduction In bilaterally symmetric nervous systems, many axons are guided to the midline of the central nervous system (CNS) by proteins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2277–2287.
Published: 01 July 2008
... guidance on the contralateral side of the corpus callosum. J. Neurosci. 26 , 5840 -5848. Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. and Soriano,P. ( 1999 ). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18 , 2459 -2471. Knoll, B...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2127–2137.
Published: 15 June 2008
... follicle development and initiating the ovulation process. * Author for correspondence (e-mail: joanner@bcm.edu ) 22 4 2008 © 2008. 2008 Ovary Ovulation Granulosa cell Kras ( K-ras ) Signal transduction MKP3 (DUSP6) Activation of small G-proteins within the RAS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (5): 989–997.
Published: 01 March 2007
... transcription. We find it curious that uniformly overexpressed SoxN represses Wg signal transduction in dorsal epidermal cells more severely than in ventral cells. This effect is evident in both cuticle pattern elements and in en expression, and is reminiscent of defects observed in the`transport...
Includes: Supplementary data