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Keywords: Signal transduction
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Journal Articles
Journal: Development
Development (2022) 149 (6): dev200159.
Published: 16 March 2022
... of the Hedgehog pathway, Engrailed, Suppressor of Fused and Roadkill modulate Cubitus interruptus expression and the competition between its activator and repressor forms. Hedgehog Signal transduction Pathway modulation Drosophila Northwestern University http://dx.doi.org/10.13039/100007059...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev192351.
Published: 7 December 2020
... Signal transduction Vascular biology Venous valves The Ras signaling pathway is a ubiquitous intracellular signaling pathway that is triggered by different growth factor receptors (GFR) in numerous cell types ( Buday and Downward, 2008 ; Wennerberg et al., 2005 ). Ras is a small GTP-binding...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (6): dev175703.
Published: 18 March 2020
... and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev176073.
Published: 15 May 2019
... of Biologists Ltd 2019 Summary: This Review describes the trafficking mechanisms proposed to mediate the extracellular transport of Wnt proteins and discusses how they contribute to Wnt dispersal. Cytoneme Exosome Secretion Signal transduction Wnt signalling Wnt trafficking...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
... straightforward signal transduction cascades impact virtually every developmental process, from cell fate specification to morphogenesis. BMP Cancer TGFβ Signal transduction Summary: This Meeting Review of the 2017 FASEB conference ʻThe TGFβ Superfamily: Signaling in Development and Disease...
Journal Articles
Journal: Development
Development (2017) 144 (19): 3612–3624.
Published: 1 October 2017
... in combination with live cell imaging, reveals that the Hedgehog deployment protein Dispatched promotes cytoneme occurrence by slowing retraction rates. Cytoneme Hedgehog Dispatched Morphogen Signal transduction Approximately 4×10 6 S2 cells were plated and then transfected the following...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1841–1850.
Published: 15 May 2017
...://www.biologists.com/user-licence-1-1/ Summary: A SMO/FU positive regulatory loop nested within a multikinase phosphorylation cascade regulates high level Hedgehog signaling in the Drosophila wing imaginal disc. Drosophila Signal transduction Hedgehog Smoothened Phosphorylation Fused kinase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3582–3590.
Published: 1 October 2016
... zebrafish angiogenesis, endothelial PKA activity regulates the transition from sprouting to stabilisation of nascent vessels, preventing excessive tip cell formation and hypersprouting. Notch Angiogenesis Retina Signal transduction Sprouting Vascular development The vascular system...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1710–1720.
Published: 15 May 2016
... - 598 . 10.1016/j.celrep.2014.03.020 Summary: In the Drosophila intestine, Tankyrase is important for Wingless signaling activation in enterocytes, thus non-autonomously regulating intestinal stem cell proliferation. Axin Signal Transduction Tankyrase Wingless Wnt β-catenin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 931–942.
Published: 1 March 2015
... 2015. Published by The Company of Biologists Ltd 2015 Summary: Costal 2 must bind Fused for efficient Ci-155 processing and for Fused activation in response to Hedgehog but mapped Fused phosphorylation sites on Costal 2 are dispensable. Drosophila Hedgehog Signal Transduction Costal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4139–4148.
Published: 1 November 2014
... through plasmodesmata (PD). PD conductivity is regulated by endogenous and exogenous signals. However, the underlying signaling mechanisms remain enigmatic. In Arabidopsis , signal transduction mediated by the receptor-like kinase STRUBBELIG (SUB) contributes to inter-cell layer signaling during tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1705–1714.
Published: 15 April 2014
.../licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Fertilization Gamete interaction In vitro reconstitution Membrane microdomains Oocyte maturation Proteolysis Signal transduction Src...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3392–3401.
Published: 15 September 2012
... family of Smad co-factors. Although the core elements of the TGFβ signal transduction pathway (ligands, receptors and Smads) and their various subfamily specificities have been known for over a decade, efforts to uncover new mechanisms influencing this potent cell fate/cell cycle regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 612–621.
Published: 1 February 2012
... for effects on Hh signal transduction. Cysteine mutagenesis reveals that previously uncharacterized functional roles exist for Smo EC1 and EC2. We provide in vitro and in vivo evidence that EC1 cysteine mutation induces significant Hh-independent Smo signaling, triggering a level of pathway activation similar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 843–853.
Published: 1 March 2009
... 01701, USA § Present address: University of South Florida, Tampa, FL 33620, USA 18 12 2008 © 2009. 2009 Integrins Signal transduction Wnt genes Receptor tyrosine kinase Integrins are a major family of heterodimeric transmembrane receptors through which cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 307–316.
Published: 15 January 2009
...Hongge Jia; Yajuan Liu; Wei Yan; Jianhang Jia The seven-transmembrane protein Smoothened (Smo) and Zn-finger transcription factor Ci/Gli are crucial components in Hedgehog (Hh) signal transduction that mediates a variety of processes in animal development. In Drosophila , multiple kinases have been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4025–4035.
Published: 15 December 2008
... aspects of axonal development in vivo. e-mail: julian.ng@kcl.ac.uk 15 10 2008 © 2008. 2008 Neural development Signal transduction Cytoskeleton Drosophila In developing neurons, axon and dendrite extensions are directed by specialised motile structures termed growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3839–3848.
Published: 1 December 2008
... Syndrome. * Author for correspondence (e-mail: tkidd@unr.edu ) 22 9 2008 © 2008. 2008 Drosophila genetics Axon guidance Body patterning Cell migration Central nervous system Signal transduction In bilaterally symmetric nervous systems, many axons are guided...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2277–2287.
Published: 1 July 2008
... family kinase Wnt Signal transduction During the development of the nervous system, axons are guided by attractive and repulsive guidance cues( Dickson, 2002 ). The ventral midline of the Drosophila embryonic nervous system has proven to be an excellent model system in which to identify...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2127–2137.
Published: 15 June 2008
... follicle development and initiating the ovulation process. * Author for correspondence (e-mail: joanner@bcm.edu ) 22 4 2008 © 2008. 2008 Ovary Ovulation Granulosa cell Kras ( K-ras ) Signal transduction MKP3 (DUSP6) Activation of small G-proteins within the RAS...
Includes: Supplementary data