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Keywords: Shuttling
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Journal Articles
Journal: Development
Development (2019) 146 (21): dev181487.
Published: 12 November 2019
... a sharp gradient is formed within this dynamic environment, we followed the generation of graded nuclear Dorsal protein, the hallmark of pattern formation along the dorso-ventral axis, in live embryos. The dynamics indicate that a sharp extracellular gradient is formed through diffusion-based shuttling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4450–4461.
Published: 1 December 2017
... of the syncytial blastoderm. Here, we use modeling and experimental studies to show that this accumulation is caused by facilitated diffusion, or shuttling, of the Dorsal/Cactus complex. We also show that active Toll receptors are limiting in wild-type embryos, which is a key factor in explaining global Dorsal...
Includes: Supplementary data