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Keywords: Shroom3
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Journal Articles
Journal: Development
Development (2015) 142 (7): 1305–1314.
Published: 1 April 2015
... actin dynamics are blocked, we examined the cellular basis of the neural tube closure defect in mouse mutants that lack the actin-severing protein cofilin 1 (CFL1). Although apical localization of the adherens junctions, the Par complex, the Crumbs complex and SHROOM3 is normal in the mutants, CFL1 has...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (1): 226–236.
Published: 1 January 2013
... by The Company of Biologists Ltd Live imaging Mouse embryogenesis Neural tube closure Shroom3 Non-neural ectoderm Live imaging of the mouse embryo is very challenging as the embryo develops in utero , unlike other model organisms such as Drosophila, Xenopus , zebrafish and chick...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4571–4581.
Published: 15 December 2012
... constriction and rosette assembly. We show that apical constriction in the LL primordium requires the activity of non-muscle myosin. We demonstrate further that shroom3 , a well-known regulator of non-muscle myosin activity, is expressed in the LL primordium and that its expression requires FGF signalling...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1599–1610.
Published: 1 May 2012
... restored normal neurogenesis. Experimental expansion of the apical domain, through inhibition of Shroom3, also increased Notch activity and reduced neurogenesis. Significantly, in wild-type retina, neurogenic retinal progenitors had smaller apical domains compared with proliferative neuroepithelia...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4423–4432.
Published: 15 October 2011
...-dependent apicobasal elongation, rather than by progressive epithelial stratification as was previously thought. Finally, we show that the actin-binding protein Shroom3 is crucial for the maintenance of the single-layered pseudostratified epithelium. In mice lacking Shroom3, the epithelium is disorganized...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 405–415.
Published: 1 February 2010
... placode is dependent on Shroom3, a molecule previously associated with apical constriction during morphogenesis of the neural plate. We show that Shroom3 is required for the apical localization of F-actin and myosin II, both crucial components of the contractile complexes required for apical constriction...