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Keywords: Shh
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev194597.
Published: 29 April 2021
... required for the progression of tooth development. IK cell dynamics demonstrate the hallmarks of a signaling center: cell cycle exit, condensation and eventual silencing through apoptosis. IK initiation and maturation are defined by the juxtaposition of cells with high Wnt activity to Shh -expressing non...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev186023.
Published: 04 June 2020
... proliferation and patterning is identified involving protein-protein interactions. Dental epithelial stem cells Pitx2 Shh Signaling centers Sox2 Transcriptional regulation Stem cell niche Craniofacial/tooth development Irx1 Enamel knot Pituitary homeobox 2 ( Pitx2 ), is a crucial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev188821.
Published: 06 May 2020
..., we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional information required for the formation of adult flight feathers in a defined spatial and temporal sequence that reflects their different identities. We also reveal that Shh signalling is interpreted into...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev179523.
Published: 30 September 2019
...Iain Williamson; Lauren Kane; Paul S. Devenney; Ilya M. Flyamer; Eve Anderson; Fiona Kilanowski; Robert E. Hill; Wendy A. Bickmore; Laura A. Lettice ABSTRACT Topologically associating domains (TADs) have been proposed to both guide and constrain enhancer activity. Shh is located within a TAD known...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev167379.
Published: 02 November 2018
...Tanya S. Corman; Solsire E. Bergendahl; Douglas J. Epstein ABSTRACT Sonic hedgehog (Shh) plays well characterized roles in brain and spinal cord development, but its functions in the hypothalamus have been more difficult to elucidate owing to the complex neuroanatomy of this brain area. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (3): dev146910.
Published: 31 January 2018
... thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4 + CD8 + to CD4 + CD8 − single-positive (SP4) cells in the fetal thymus and that Gli3 represses Shh . Constitutive deletion of Gli3 , and conditional deletion of Gli3 from TECs, reduced differentiation to SP4, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3278–3288.
Published: 15 September 2017
... differentiate into mammillary cells. A stable population of Fgf10 + progenitors is retained within the tuberal domain; a subset of these gives rise to the tuberal infundibulum – the precursor of the posterior pituitary. Pharmacological approaches reveal that Shh signalling promotes the growth and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3054–3065.
Published: 01 September 2017
... taste bud cells, but not progenitor proliferation, is interrupted in mice treated with a hedgehog (Hh) pathway inhibitor (HPI), and that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal. Additionally, epithelial taste precursor cells express Shh transiently, and provide a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2652–2662.
Published: 15 July 2017
... + progenitor population relies on the activity of the Shh, Wnt and Fgf signaling pathways. Wnt and Fgf function additively to generate dHb progenitors. Surprisingly, Wnt signaling also negatively regulates fgf8a , confining expression to a discrete dorsal diencephalic domain. Moreover, the Wnt and Fgf pathways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1906–1917.
Published: 15 May 2017
...-licence-1-1/ Summary: Sox17 haploinsufficiency in the gallbladder induces ectopic cystic duct-like epithelia and defective smooth muscle formation by reduced Shh signals. Gallbladder Biliary atresia Sox17 Shh The gallbladder is a flexible organ of the biliary tract that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 400–408.
Published: 01 February 2017
... adult urothelial progenitors. Without Eed , the obligatory subunit of PRC2, embryonic urothelial progenitors demonstrate reduced proliferation with concomitant dysregulation of genes including Cdkn2a ( p16 ), Cdkn2b ( p15 ) and Shh. These mutants display premature differentiation of keratin 5-positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3514–3521.
Published: 01 October 2016
...Joseph Pickering; Matthew Towers In an influential model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud specifies cells with three antero-posterior positional values, which give rise to three morphologically different digits by a self-organizing mechanism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 691–702.
Published: 15 February 2016
... Summary: Analyses of the mDA neuron marker genes Pitx3 and Aldh1a1 in chick and mouse suggest important differences in how mDA neurons are generated in these species. Dopamine precursors Chicken Mouse PITX3 WNT9a SHH Funding A.A.P.A. was partly supported by a Future grant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (22): 3810–3820.
Published: 15 November 2015
... regulatory networks that govern limb development, fin-to-limb transition and digit reductions during tetrapod limb evolution. SHH WNT BMP FGF HOXA HOXD Topological domains Turing Teleost For over 60 years, vertebrate limb bud development has been one of the most prominent experimental...
Journal Articles
Journal: Development
Development (2015) 142 (22): 3933–3942.
Published: 15 November 2015
... partitioned into prospective nasal and temporal domains by the opposing actions of Fgfs and Shh emanating from dorsal and ventral domains of the forebrain primordium. In absence of Fgf activity, foxd1 expression is established irrespective of levels of Hh signalling, indicating that the role of Shh in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3374–3382.
Published: 01 October 2015
... correspondence ( ychai@usc.edu ) Competing interests The authors declare no competing or financial interests. 1 6 2015 31 7 2015 © 2015. Published by The Company of Biologists Ltd 2015 Summary: During tooth development in mice, Nfic binds to Hhip to control Shh signaling, a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2981–2995.
Published: 01 September 2015
... congenital cystic lung diseases. The cystic lung phenotype in Yy1 mutants can be partly explained by the reduced expression of Shh , a transcriptional target of YY1, in lung endoderm, and the subsequent derepression of mesenchymal Fgf10 expression. Accordingly, SHH supplementation partially rescued the lung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2291–2303.
Published: 01 July 2015
...Magdalena Stasiulewicz; Shona D. Gray; Ioanna Mastromina; Joana C. Silva; Mia Björklund; Philip A. Seymour; David Booth; Calum Thompson; Richard J. Green; Emma A. Hall; Palle Serup; J. Kim Dale Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patterning of the overlying neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1561–1571.
Published: 01 May 2015
... Ltd 2015 Summary: This Review compares the mechanisms at play during inner ear hair cell development and regeneration, highlighting gaps in our knowledge and proposing future directions in research and therapeutics. Wnt FGF Shh Notch Atoh1 p27 Kip1 , Cdkn1b Funding This...
Journal Articles
Journal: Development
Development (2015) 142 (3): 567–574.
Published: 01 February 2015
... show that hierarchical induction mechanisms, consisting of iterative signaling by Sonic hedgehog (SHH) followed by Bone morphogenetic proteins (BMPs), regulate a dynamic expression pattern of Shh in the ectoderm covering the frontonasal (FNP) and maxillary (MxP) processes. Furthermore, this Shh...
Includes: Supplementary data