...Jamila I. Horabin Sex-lethal ( Sxl ), the Drosophila sex-determination master switch, is on in females and controls sexual development as a splicing and translational regulator. Hedgehog (Hh) is a secreted protein that specifies cell fate during development. Previous work has demonstrated that Sxl...

...Jamila I. Horabin; Sabrina Walthall; Cynthia Vied; Michelle Moses The sex determination master switch, Sex-lethal ( Sxl ) , controls sexual development as a splicing and translational regulator. Hedgehog (Hh) is a secreted protein that specifies cell fate during development. We show that Sxl...

...Cynthia Vied; Jamila I. Horabin Sex-lethal is the Drosophila melanogaster sex determination master switch. It is also required in female germ cells to control mitosis and meiotic recombination. As early germ cells mature, distinct changes in both Sex-lethal protein levels and localization occur...

... functioning of Sex-lethal ( Sxl ) which is primarily known as the master gene in somatic sex determination. Certain alleles of this gene ( Sxl fs ) disrupt the germline, but not the somatic function of Sxl and cause an arrest of germ cell development during cystocyte proliferation. Using dominant suppressor...

...Ananya Bhattacharya; S. Sudha; H. Sharat Chandra; Ruth Steward The Sex-lethal (Sxl) gene is required in Drosophila females for sexual differentiation of the soma, for gem cell differentiation and dosage compensation. We have isolated three new alleles of female-lethal-on-X (flex), an X-linked...

... ). The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal . Genes Dev . 5 , 2176 – 2187 . 10.1101/gad.5.12a.2176 Duffy , J. B. , Kania , M. A. and Gergen , J. P. ( 1991 ). Expression...

...Girish Deshpande; Gretchen Calhoun; Paul D. Schedl ABSTRACT Sex determination in Drosophila depends upon the post-transcriptional regulatory activities of the Sex-lethal (Sxl) gene. Sxl maintains the female determined state and activates female differentiation pathways by directing the female...

... in the segmentation pathway. Here we demonstrate that runt also functions to activate transcription. The initial expression of the female-specific sex-determining gene Sex-lethal in the blastoderm embryo requires runt activity. Consistent with a role as a direct activator, Runt shows sequence-specific binding...

... ) 12 02 1998 © 1998 by Company of Biologists 1998 Sex-lethal Sex determination Ceratitis Drosophila Evolution In Drosophila melanogaster , the primary sex-determining signal is based on the number of X chromosomes in relation to the sets of autosomes (reviewed by Cline...

...Martin Meise; Denise Hilfiker-Kleiner; Andreas Dübendorfer; Claudia Brunner, Rolf Nöthiger; Daniel Bopp ABSTRACT Sex-lethal (Sxl) is the master switch gene for somatic sex determination in Drosophila melanogaster . In XX animals, Sxl becomes activated and imposes female development; in X(Y) animals...

...Jeffrey H. Hager; Thomas W. Cline ABSTRACT With a focus on Sex-lethal ( Sx1 ), the master regulator of Drosophila somatic sex determination, we compare the sex determination mechanism that operates in the germline with that in the soma. In both cell types, Sx1 is functional in females (2X2A...

...Daniel Bopp; Gretchen Calhoun; Jamila I. Horabin; Mark Samuels; Paul Schedl ABSTRACT In D. melanogaster the binary switch gene Sex-lethal ( Sxl ) plays a pivotal role in somatic sex determination – when the Sxl gene is on the female pathway is followed, while the male pathway is followed when...

... of these sex determination cues are required for female-specific Sex-lethal + function in germ cells. The ovo + locus encodes zinc finger protein(s) required for female-specific splicing of Sex-lethal + pre-mRNA, making ovo + a candidate function acting between the two principal cues and Sex-lethal + . We have...

... pathway chosen by the cells depends on the gene Sex-lethal (Sxl) , whose function is continuously needed for female development. In the soma, the sex of the cells is autonomously determined by the X:A signal while, in the germ line, the sex is determined by cell autonomous (the X:A signal) and somatic...

...Daniel Bopp; Jamila I. Horabin; Robert A. Lersch; Thomas W. Cline; Paul Schedl ABSTRACT In addition to controlling somatic sexual development in Drosophila melanogaster , the Sex-lethal (Sxl ) gene is required for proper differentiation of female germ cells. To investigate its role in germ-line...

...Monica Steinmann-Zwicky ABSTRACT In soma and germ cells of Drosophila , the X:A ratio builds a primary signal for sex determination, and in both tissues Sex-lethal ( Sxl ) function is required for cells to enter the female pathway. In somatic cells of XX animals, the products of X-chromosomal...

...Susan M. Parkhurst; Howard D. Lipshitz; David Ish-Horowicz ABSTRACT Sex determination in Drosophila depends on X-linked ‘numerator’ genes activating early Sex-lethal ( Sxl ) transcription in females. One numerator gene, sisterless-b ( sis-b ), corresponds to the achaete-scute (AS-C) T4 basichelix...

... of the gene Sexlethal (Sxl) , and (3) the sex of the gonadal soma. To this end, animals with a ratio of 2X:2A and 2X:3A were sexually transformed into pseudomales by mutations at the sex-determining genes Sxl (Sex-lethal), tra (transformer), tra-2 (transformer-2), or dsx (double-sex). Animals...