.... Previously, we have shown that the gene encoding the type II anti-Müllerian hormone receptor, amhrII , is responsible for excessive germ cell proliferation and male-to-female sex reversal in the medaka hotei mutant. In this study, functional analyses in cultured cells and of other amhrII mutant alleles...

... the anterior end of the gonad ( Fig. 3A,B ). Pod1 Tcf21 Sf1 Gonadogenesis Testis development Sex reversal Leydig cell Mammalian sexual differentiation is a complex process that begins with the establishment of genetic sex (XX or XY) at the time of fertilization. In mice,the bipotential...

.... These results indicate that GATA4 and FOG2 and their physical interaction are required for normal gonadal development. †Author for correspondence (e-mail: [email protected] ) 1 7 2002 © 2002. 2002 Testis GATA4 FOG2 Sry Sertoli cell Sex reversal Mouse Mammalian...

...). Proliferation and migration of primordial germ cells in W e /W e mouse embryos. Dev. Dyn . 198 , 182 -189. Burgoyne, P. S. and Palmer, S. J. ( 1991 ). The genetics of XY sex reversal in the mouse and other mammals. Semin. Dev. Biol . 2 , 277 -284. Capel, B. ( 2000 ). The battle...

...-mail: [email protected] ) 07 06 1999 22 04 1999 © 1999 by Company of Biologists 1999 Cell migration Mesonephros Sex determination Sex reversal Sry The mammalian gonad is a unique model system for the study of organogenesis because it is bipotential: a single...

...Claude M. Nagamine; Cherlynn Carlisle ABSTRACT The Y chromosome from certain populations of M. m. domesticus is incapable of normal testis determination in the B6 inbred strain resulting in XY hermaphrodites or XY females (XY DOM sex reversal). B6 consomic strains have been developed with either...

...Rafael Jiménez; Miguel Burgos; Antonio Sánchez; Andrew H. Sinclair; Francisco J. Alarcón; Juan J. Marín; Esperanza Ortega; Rafael Díaz de la Guardia ABSTRACT We investigated the origin of XX sex reversal in the insectivorous mole Talpa occidentalis . Cytogenetic, histological and hormonal studies...

.... , Boyse , E. A. , Wachtel , S. and Cattanach , B. M. ( 1977 ). Serological evidence for H-Y antigen in Sxr, XX sex-reversed phenotypic males . Nature, Lond . 265 , 255 – 257 . 10.1038/265255a0 Bishop , C. E. , Weith , A. , Mattei , M. G. and Roberts , C. ( 1988...

... in the mouse showing that the region is evolving very rapidly. © 1987 by Company of Biologists 1987 DNA probe sex reversal mouse 5xr sex determination The Y chromosome is the most specialized of mammalian chromosomes being involved almost exclusively in primary sex determination...

...Ulrich Müller ABSTRACT Sex reversal in males with female karyotypes is likely to be caused by the presence of cytogenetically undetectable Y-chromosomal DNA sequences that include the testis-determining gene(s). Studying a total of sixteen 46,XX males and one 47,XXX male, we detected Y-chromosomal...