... variable gonadal sex reversal phenotype in the fetal period, characterised by appearance of ovarian tissue. To investigate this sex reversal further, we used single-cell RNA-seq to examine the transcriptomes of XY Znrf3 -deficient gonads during the mouse sex-determining period. Analyses of cell...

.... Previously, we have shown that the gene encoding the type II anti-Müllerian hormone receptor, amhrII , is responsible for excessive germ cell proliferation and male-to-female sex reversal in the medaka hotei mutant. In this study, functional analyses in cultured cells and of other amhrII mutant alleles...

... steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat. Genet. 22 , 125 -126. Achermann, J. C., Ozisik, G., Ito, M., Orun, U. A., Harmanci,K., Gurakan, B. and Jameson, J. L. ( 2002 ). Gonadal determination and adrenal development are regulated by the orphan nuclear receptor...

... ). A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse. Nat. Genet . 26 , 490 -494. Bitgood, M. J., Shen, L. and McMahon, A. P. ( 1996 ). Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr. Biol . 6 , 298 -304. Buehr, M...

... development Sertoli cells Prostaglandin D synthase Prostaglandin D 2 Sex reversal Mouse In the mouse embryo, primordial germ cells (PGCs) have the potential to develop either as meiotic oocytes, progressing through the first meiotic prophase and arresting in dictyate just after birth...

...-mail: [email protected] ) 07 06 1999 22 04 1999 © 1999 by Company of Biologists 1999 Cell migration Mesonephros Sex determination Sex reversal Sry The mammalian gonad is a unique model system for the study of organogenesis because it is bipotential: a single...

...Claude M. Nagamine; Cherlynn Carlisle ABSTRACT The Y chromosome from certain populations of M. m. domesticus is incapable of normal testis determination in the B6 inbred strain resulting in XY hermaphrodites or XY females (XY DOM sex reversal). B6 consomic strains have been developed with either...

...Rafael Jiménez; Miguel Burgos; Antonio Sánchez; Andrew H. Sinclair; Francisco J. Alarcón; Juan J. Marín; Esperanza Ortega; Rafael Díaz de la Guardia ABSTRACT We investigated the origin of XX sex reversal in the insectivorous mole Talpa occidentalis . Cytogenetic, histological and hormonal studies...

... a . It is clear from the present findings that a gene (or genes) present in the deleted DNA plays a major role in the survival and proliferation of the differentiating A spermatogonia. Sex-reversed (Sxr) is a factor that causes an inherited form of sex-reversal, such that XX and XO mice carrying Sxr develop...

... in the mouse showing that the region is evolving very rapidly. © 1987 by Company of Biologists 1987 DNA probe sex reversal mouse 5xr sex determination The Y chromosome is the most specialized of mammalian chromosomes being involved almost exclusively in primary sex determination...

...Ulrich Müller ABSTRACT Sex reversal in males with female karyotypes is likely to be caused by the presence of cytogenetically undetectable Y-chromosomal DNA sequences that include the testis-determining gene(s). Studying a total of sixteen 46,XX males and one 47,XXX male, we detected Y-chromosomal...