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Keywords: Sex determination
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (5): dev201060.
Published: 13 March 2023
...Corey Bunce; Lindsey Barske; Gloria Zhang; Blanche Capel ABSTRACT During mammalian development, gonadal sex determination results from the commitment of bipotential supporting cells to Sertoli or granulosa cell fates. Typically, this decision is coordinated across the gonad to ensure commitment...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (16): dev199646.
Published: 23 August 2021
... tissue, two fates: molecular genetic events that underlie testis versus ovary development . Nat. Rev. Genet. 5 , 509 - 521 . 10.1038/nrg1381 Capel , B. ( 2017 ). Vertebrate sex determination: evolutionary plasticity of a fundamental switch . Nat. Rev. Genet. 18 , 675 - 689...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (17): dev192856.
Published: 11 September 2020
... germ cells, the testis-specific PHF7 protein acts as an oncogene with transcriptional reprogramming activity that inappropriately activates male germ cell genes. Germ cell fate Oogenesis Germline tumors Sex determination Germ cell development culminates in the production of sexually...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (4): dev181693.
Published: 25 February 2020
... signalling is mediated via estrogen receptor alpha within the left gonad epithelium. However, the presence of a medulla with an ‘intersex’ or male phenotype may compromise germ cell progression into meiosis, causing cortical germ cells to remain in an immature state in the embryo. At sex determination...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (4): 720–730.
Published: 15 February 2017
... challenging in the context of developing tissues where material is limited and cell types are mixed. To identify regulatory sites during sex determination, we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and ChIP-seq for H3K27ac. DNaseI-seq identified putative regulatory sites around genes...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (4): 720–730.
Published: 15 February 2017
... challenging in the context of developing tissues where material is limited and cell types are mixed. To identify regulatory sites during sex determination, we subjected Sertoli cells from mouse fetal testes to DNaseI-seq and ChIP-seq for H3K27ac. DNaseI-seq identified putative regulatory sites around genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1633–1637.
Published: 15 May 2016
... was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry . This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what...
Journal Articles
Journal: Development
Development (2015) 142 (6): 1083–1088.
Published: 15 March 2015
...Liang Zhao; Terje Svingen; Ee Ting Ng; Peter Koopman Genes related to Dmrt1 , which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species. However, this role is fulfilled in mammals by Sry , a newly evolved gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 575–586.
Published: 1 February 2015
...Quan Wu; Kurumi Fukuda; Michael Weinstein; Jonathan M. Graff; Yumiko Saga The sex of primordial germ cells (PGCs) is determined in developing gonads on the basis of cues from somatic cells. In XY gonads, sex-determining region Y (SRY) triggers fibroblast growth factor 9 (FGF9) expression in somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2195–2205.
Published: 1 June 2014
...Christian Larney; Timothy L. Bailey; Peter Koopman Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y ( Sry ). Reduced or delayed Sry expression impairs testis...
Journal Articles
Journal: Development
Development (2011) 138 (13): 2761–2771.
Published: 1 July 2011
... ) Competing interests statement The authors declare no competing financial interests. 22 4 2011 © 2011. 2011 DamID Doublesex Evolution Sex determination Transcription factor binding site Although many of the regulatory hierarchies governing development have been elucidated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1759–1769.
Published: 1 May 2011
... at times when HES family members are active and limits Hey and HES family activity during sex determination, segmentation and neurogenesis. We show that Dgrn interacts with the Notch signaling pathway by it antagonizing the activity of E(spl)-C proteins. dgrn null mutants are female sterile, producing...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 3921–3930.
Published: 1 December 2010
...Kenichi Kashimada; Peter Koopman SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which...
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (2): 323–332.
Published: 15 January 2010
... the tools for dissecting how neurogenesis and neuronal differentiation are modulated by the Drosophila sex-determination regulatory genes to produce nervous system sexual dimorphisms. Here we report studies aimed at illuminating the basis of the sexual dimorphic axonal projection patterns of foreleg...
Includes: Supplementary data