...Corey Bunce; Lindsey Barske; Gloria Zhang; Blanche Capel ABSTRACT During mammalian development, gonadal sex determination results from the commitment of bipotential supporting cells to Sertoli or granulosa cell fates. Typically, this decision is coordinated across the gonad to ensure commitment...

...Diane Rebourcet; Peter J. O'Shaughnessy; Jean-Luc Pitetti; Ana Monteiro; Laura O'Hara; Laura Milne; Yi Ting Tsai; Lyndsey Cruickshanks; Dieter Riethmacher; Florian Guillou; Rod T. Mitchell; Rob van ’t Hof; Tom C. Freeman; Serge Nef; Lee B. Smith Sertoli cells (SCs) regulate testicular fate...

...Robert W. Holdcraft; Robert E. Braun Androgen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement is thought to be mediated by Sertoli cells and its genetic...

... seminiferous epithelium have been well characterised, particularly in rodent species, their developmental origins are unknown. We show that the Sertoli cells of the pre-pubertal mouse, including those of the germ cell-deficient XX Sxra mutant, exhibit coordinated, cyclical patterns of gene expression...

..., expression was restricted to Sertoli cells and their precursors, the embryonic tunica albuginea and the rete testis. The intracellular distribution of the WT1 protein was investigated by confocal laser microscopy and was demonstrated to be exclusively nuclear. The nuclear distribution and the selective...