... of differentiation inhibit their neighbours from doing likewise: the committed cells express Notch ligand(s)(of the Delta or Serrate/Jagged family) and deliver inhibition by activating Notch in their neighbours ( Heitzler and Simpson, 1991 ). A hallmark of lateral inhibition is the negative regulation of Notch...

... concerning the genes required for survival during the early cell-proliferation phase. Here, we show that Lobe ( L ) and the Notch (N) ligand Serrate ( Ser ), which are both involved in ventral eye growth, are required for cell survival in the early eye disc. We observed that the loss-of-ventral-eye phenotype...

...Weidong Wang; Gary Struhl Ligands of the Delta/Serrate/Lag2 (DSL) family must normally be endocytosed in signal-sending cells to activate Notch in signal-receiving cells. DSL internalization and signaling are promoted in zebrafish and Drosophila , respectively, by the ubiquitin ligases Mind bomb...

...Eric C. Lai; Fabrice Roegiers; Xiaoli Qin; Yuh Nung Jan; Gerald M. Rubin The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central components in the Notch pathway, a fundamental cell signaling system that regulates pattern formation during animal development. Delta...

... of Wg and Cut( Neumann and Cohen, 1996 ), the latter operating as a transcriptional repressor of Dl . In parallel,Wg activates expression of Dl and Serrate in the juxta-margin cells. High levels of Dl and Serrate prevent Notch activation in these cells( de Celis and Bray, 1997 ; Micchelli et al., 1997...

... Serrate The body appendages of insects, spiders and crustaceans show a high degree of variation between species. The numerous modifications of the appendages contributed substantially to the evolutionary success of the arthropods. Within an individual, limbs are also morphologically distinct...

... signaling molecules. In order to understand how the integration of multiple signaling pathways and selector proteins can be achieved during wing development, we studied the regulatory network that controls the expression of Serrate (Ser), a ligand for the Notch(N) signaling pathway, which is essential...

... pannier ( pnr ) controls Iroquois-Complex ( Iro-C ) genes to establish the dorsal eye fate whereas Lobe ( L ), which is involved in controlling a Notch ligand Serrate ( Ser ), is specifically required for ventral growth. However, fate of eye disc cells before the onset of dorsal expression of pnr and Iro...

.... * Author for correspondence (e-mail: [email protected] ) 28 8 2003 © 2003. 2003 SMAD Delta Serrate TGFβ skeletal muscle γ-secretase inhibitor Notch signaling is an evolutionarily well-conserved system for cell-cell communication ( Artavanis-Tsakonas et al.,1999...

... ) 10 9 2002 ©2002. 2002 Notch signalling hnRNP I Delta Serrate Polypyrimidine tract binding protein (PTB) RRM RNA-binding proteins hephaestus Lateral inhibition describes the intercellular interactions that subdivide initially equivalent populations through...

... arise. I further demonstrate that the proximal-distal patterning genes homothorax and dachshund are positively required, while Distal-less is unexpectedly negatively required, to establish the segmental pattern of Notch ligand and fringe expression. Two Serrate enhancers that respond to regulation...

... between these pathways. Surprisingly, we find that although four-jointed expression is regulated downstream of Notch activation, four-jointed can induce expression of the Notch ligands, Serrate and Delta, and may thereby participate in a feedback loop with the Notch signaling pathway. We also show...

... evidence that activation of Notch by its ligand Serrate apportions myogenic and non-myogenic cell fates within the early Xenopus heart field. The crescent-shaped field of heart mesoderm is specified initially as cardiomyogenic. While the ventral region of the field forms the myocardial tube...

...Nicola Lawrence; Thomas Klein; Keith Brennan; Alfonso Martinez Arias The Delta and Serrate proteins interact with the extracellular domain of the Notch receptor and initiate signalling through the receptor. The two ligands are very similar in structure and have been shown to be interchangeable...

... development by its target gene dLMO . Apterous-dependent expression of Serrate and fringe in dorsal cells leads to the restricted activation of Notch along the dorsoventral compartment boundary. We present evidence that the ability of cells to participate in this Apterous-dependent cell-interaction is under...

...S. A. Bishop; T. Klein; A. Martinez Arias; J. P. Couso ABSTRACT The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments...

... architecture. We have identified the Drosophila signaling protein Serrate as the product of a Hox downstream gene that acts in many segments as a component of such pathways. In the embryonic epidermis, Serrate is required for morphogenesis of normal abdominal denticle belts and maxillary mouth hooks, both Hox...

... gene expression. Similar misregulation of delta genes is seen in the ear, along with misregulation of a Serrate homologue, serrateB , coding for an alternative Notch ligand. Most dramatically, the sensory patches in the mind bomb ear consist solely of hair cells, which are produced in great excess...

...Thomas L. Jacobsen; Keith Brennan; Alfonso Martinez Arias; Marc A. T. Muskavitch ABSTRACT We find that ectopic expression of Delta or Serrate in neurons within developing bristle organs is capable of non-autonomously inducing the transformation of the pre-trichogen cell into a tormogen cell...

..., which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule. The other Notch ligand, Delta, also plays a role in the development and patterning of the wing. It has been proposed that Fringe modulates the ability of Serrate and Delta to signal through Notch and thereby...