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Keywords: Serotonin
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Journal Articles
Journal: Development
Development (2016) 143 (14): 2616–2628.
Published: 15 July 2016
... for cholecystokinin and secretin production. In all stages and Nkx2.2 mutant conditions, serotonin-producing enterochromaffin cells were the most severely reduced enteroendocrine lineage in the duodenum and colon. We determined that the transcription factor Lmx1a is expressed in enterochromaffin cells and functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 516–529.
Published: 01 February 2016
... Glutamate Dopamine Serotonin Midbrain Hindbrain Mouse Chicken Midbrain dopaminergic (DA) and dorsal raphe serotonergic (5-HT) neurons regulate responses to reward and punishment, associative learning, mood, and coordination of voluntary movements. Function of these monoaminergic pathways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3370–3377.
Published: 01 September 2014
... (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1526–1533.
Published: 01 April 2014
... epidermis, characterized by serotonin synthesis and secretion. It is termed small secretory cell (SSC). SSCs are detectable at early tadpole stages, unlike MCCs and ISCs, which are specified at early neurulation. Subcellularly, serotonin was found in large, apically localized vesicle-like structures, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3473–3484.
Published: 15 August 2011
... type differentiation. * Authors for correspondence ( kapsimal@biologie.ens.fr ; rosa@biologie.ens.fr ) Competing interests statement The authors declare no competing financial interests. 14 6 2011 © 2011. ascl1a sox2 Calbindin 2 Serotonin Pharyngeal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2927–2937.
Published: 01 September 2010
...Elisa Reisoli; Stefania De Lucchini; Irma Nardi; Michela Ori Serotonin (5-HT) is a neuromodulator that plays many different roles in adult and embryonic life. Among the 5-HT receptors, 5-HT2B is one of the key mediators of 5-HT functions during development. We used Xenopus laevis as a model system...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (14): 2477–2485.
Published: 15 July 2009
..., Lmx1b and Gata2 is markedly downregulated. Nevertheless, serotonergic precursors begin to differentiate in Insm1 mutants, but fail to produce serotonin because of a failure to activate expression of tryptophan hydroxylase 2 (Tph2), the key enzyme of serotonin biosynthesis. We find that both Insm1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 253–262.
Published: 15 January 2009
... to demonstrate a requirement for Gata2 for the differentiation of serotonin-positive cells in r1( Craven et al., 2004 ). Consistent with this, our results show loss of serotonergic neurons in the conditional Gata2 mutants. In contrast to the Gata2 mutant explant cultures, our results suggest that loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3271–3280.
Published: 01 October 2008
... activity sustained elevated Ca i 2+ . On the right, Ca i 2+ levels were actively repressed through the activities of H + K + ATPase and serotonin-dependent signaling, thus identifying a novel mechanism for the known effects of serotonin on laterality. Vitamin A-deficient quail have a high incidence...
Journal Articles
Journal: Development
Development (2004) 131 (15): 3671–3680.
Published: 01 August 2004
... providing a link between environmental signals and developmental regulation. Induced retardation starts from the trochophore stage and results in up to twofold prolongation of the larval lifespan. Upon stimulation with the signal, the neurones increase synthesis and release of monoamines [serotonin (5-HT...
Journal Articles
Journal: Development
Development (2004) 131 (5): 997–1006.
Published: 01 March 2004
... connections are forming. Although serotonin is a highly conserved neurotransmitter that is important for many CNS functions, little is known about the process of serotonergic neuron differentiation. We show that in Drosophila ,expression of the serotonin transporter (SerT) is both temporally and physically...
Journal Articles
Journal: Development
Development (2002) 129 (16): 3901–3911.
Published: 15 August 2002
...; the neurons are generated but do not express genes necessary for serotonergic neurotransmission. unc-86 -null mutations affect the expression in NSM of tph-1 , which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1 , which encodes a vesicular transporter that loads serotonin...
Journal Articles
Journal: Development
Development (2002) 129 (4): 1027–1036.
Published: 15 February 2002
... patterns. Mech. Dev . 36 , 87 -102. Lundell, M. J., Chu-LaGraff, Q., Doe, C. Q. and Hirsh, J. ( 1996 ). The engrailed and huckebein genes are essential for development of serotonin neurons in the Drosophila CNS. Mol. Cell Neurosci . 7 , 46 -61. Lundell, M. J. and Hirsh, J. ( 1998...