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Keywords: Septation
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Journal Articles

Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development

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Matthew M. Goddeeris, Robert Schwartz, John Klingensmith, Erik N. Meyers
Journal: Development
Development (2007) 134 (8): 1593–1604.
https://doi.org/10.1242/dev.02824
Published: 15 April 2007
...Matthew M. Goddeeris; Robert Schwartz; John Klingensmith; Erik N. Meyers Cardiac outflow tract (OFT) septation is crucial to the formation of the aortic and pulmonary arteries. Defects in the formation of the OFT can result in serious congenital heart defects. Two cell populations, the anterior...
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Includes: Supplementary data
Journal Articles

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression

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Lucile Miquerol, B. Lowell Langille, Andras Nagy
Journal: Development
Development (2000) 127 (18): 3941–3946.
https://doi.org/10.1242/dev.127.18.3941
Published: 15 September 2000
... of VEGF-A from its endogenous locus results in severe abnormalities in heart development and embryonic lethality at E12.5-E14. The mutant embryos displayed an attenuated compact layer of myocardium, overproduction of trabeculae, defective ventricular septation and abnormalities in remodeling...
View articletitled, Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
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