.... Published by The Company of Biologists Ltd 2014 Otic specification Morphogenesis Sensory patch Maculae Cristae Semicircular canals Endolymphatic system Tegmentum vasculosum Compartment Cell lineage Modeling any developing organ of an organism is an attempt to rationally systematize...

...Fan-Suo Geng; Leila Abbas; Sarah Baxendale; Celia J. Holdsworth; A. George Swanson; Krasimir Slanchev; Matthias Hammerschmidt; Jacek Topczewski; Tanya T. Whitfield Morphogenesis of the semicircular canal ducts in the vertebrate inner ear is a dramatic example of epithelial remodelling in the embryo...

...Staci Rakowiecki; Douglas J. Epstein The morphogenetic program that shapes the three semicircular canals (SSCs) must be executed with extreme precision to satisfy their complex vestibular function. The SSCs emerge from epithelial outgrowths of the dorsal otocyst, the central regions of which fuse...

...Weise Chang; John V. Brigande; Donna M. Fekete; Doris K. Wu In the vertebrate inner ear, the ability to detect angular head movements lies in the three semicircular canals and their sensory tissues, the cristae. The molecular mechanisms underlying the formation of the three canals are largely...

... is not clear. In order to understand the biological role of Dfna5, we took a reversegenetic approach in zebrafish. Here we show that morpholino antisense nucleotide knock-down of dfna5 function in zebrafish leads to disorganization of the developing semicircular canals and reduction of pharyngeal cartilage...

...Catherine M. Haddon; Julian H. Lewis ABSTRACT The membranous labyrinth of the inner ear, with its three semicircular canals, originates from a simple spheroidal otic vesicle. The process is easily observed in Xenopus . The vesicle develops three dorsal outpocketings; from the two opposite faces...