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Keywords: Self-renewal
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Journal Articles
Journal: Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
... variability and improving the efficiency, reproducibility and reliability of embryonic stem cell culture. Differentiation Embryonic stem cells Pluripotency Self-renewal Mouse embryonic stem (ES) cells are cell lines derived from the pre-implantation epiblast of mouse embryos ( Boroviak et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev156059.
Published: 18 February 2019
..., are generated. Recent studies have significantly modified earlier views on the mechanisms of NSC self-renewal and neurogenesis in the adult brain. Here, we discuss the molecular control, heterogeneity, regional specification and cell division modes of V-SVZ NSCs, and draw comparisons with NSCs in the...
Journal Articles
Journal: Development
Development (2018) 145 (2): dev154534.
Published: 25 January 2018
...Caroline Dillard; Karine Narbonne-Reveau; Sophie Foppolo; Elodie Lanet; Cédric Maurange ABSTRACT Whether common principles regulate the self-renewing potential of neural stem cells (NSCs) throughout the developing central nervous system is still unclear. In the Drosophila ventral nerve cord and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 235–247.
Published: 15 January 2017
... myogenic commitment and differentiation, timely repression of their activity is necessary for the self-renewal and maintenance of muscle stem cells (satellite cells). Here, we define Ascl2 as a novel inhibitor of MRFs. During mouse development, Ascl2 is transiently detected in a subpopulation of Pax7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4312–4323.
Published: 01 December 2016
...Xing Ma; Yingying Han; Xiaoqing Song; Trieu Do; Zhihao Yang; Jianquan Ni; Ting Xie Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell self-renewal and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3097–3108.
Published: 01 September 2016
... facilitates the membrane localization of GLP-1 /Notch. Self-renewal Differentiation STRIPAK Far complex Germ cells A GFP fusion of the transmembrane yolk receptor RME-2 ( Grant and Hirsh, 1999 ), which was not detectable in the cytoplasm of wild-type oocytes, accumulated around the nucleus in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
...Jun Yu; Xiang Lan; Xia Chen; Chao Yu; Yiwen Xu; Yujuan Liu; Lingna Xu; Heng-Yu Fan; Chao Tong The homeostasis of self-renewal and differentiation in stem cells is controlled by intrinsic signals and their niche. We conducted a large-scale RNA interference (RNAi) screen in Drosophila testes and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 575–581.
Published: 15 February 2016
... divisions to maintain self-renewability during mammalian neurogenesis . Nat. Cell Biol.   10 , 93 - 101 . 10.1038/ncb1673 Lancaster , M. A. and Knoblich , J. A. ( 2012 ). Spindle orientation in mammalian cerebral cortical development . Curr. Opin. Neurobiol.   22 , 737 - 746...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1572–1581.
Published: 01 May 2015
... re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors...
Journal Articles
Journal: Development
Development (2015) 142 (7): 1228–1241.
Published: 01 April 2015
...Yuwen Li; Jiao Liu; Wencheng Li; Aaron Brown; Melody Baddoo; Marilyn Li; Thomas Carroll; Leif Oxburgh; Yumei Feng; Zubaida Saifudeen Contrary to its classic role in restraining cell proliferation, we demonstrate here a divergent function of p53 in the maintenance of self-renewal of the nephron...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 41–50.
Published: 01 January 2015
... goblet cell lineage that partially mimics Notch loss-of-function defects. Finally, we provide evidence that Bmi1 contributes to ISC self-renewal. * These authors contributed equally to this work ‡ Authors for correspondence ( abigas@imim.es ; lespinosa@imim.es ) Competing interests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4697–4709.
Published: 15 December 2014
...Chen-yan Ma; Mao-jin Yao; Qi-wei Zhai; Jian-wei Jiao; Xiao-bing Yuan; Mu-ming Poo The balance between self-renewal and differentiation of adult neural stem cells (aNSCs) is essential for the maintenance of the aNSC reservoir and the continuous supply of new neurons, but how this balance is fine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4087–4097.
Published: 01 November 2014
...Sowmya Parameswaran; Xiaohuan Xia; Ganapati Hegde; Iqbal Ahmad In vertebrate retina, histogenesis occurs over an extended period. To sustain the temporal generation of diverse cell types, retinal progenitor cells (RPCs) must self-renew. However, self-renewal and regulation of RPCs remain poorly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1649–1659.
Published: 15 April 2014
... differentiation of LRCs in vitro and impaired satellite cell self-renewal after muscle injury. By contrast, loss of p21 cip1 only affected nonLRCs, in which myogenic commitment was inhibited. Our results provide evidence that restriction of self-renewal potential to LRCs is established early in life and is...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4155–4164.
Published: 15 October 2013
... cell self-renewal and differentiation; they divide asymmetrically to self-renew and generate the neurons and glia of the CNS. Here we report the identification of midlife crisis ( mdlc ; CG4973 ) as a gene required for the maintenance of neuronal differentiation and for neuroblast proliferation in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3532–3540.
Published: 01 September 2013
...Xiankun Zeng; Xinhua Lin; Steven X. Hou The proportion of stem cells versus differentiated progeny is well balanced to maintain tissue homeostasis, which in turn depends on the balance of the different signaling pathways involved in stem cell self-renewal versus lineage-specific differentiation. In...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2525–2534.
Published: 15 June 2013
... ( luciano.dicroce@crg.eu ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Polycomb Stem cells Transcription Differentiation Self-renewal Although stem cells were discovered decades ago ( Till...
Journal Articles
Journal: Development
Development (2013) 140 (9): 1882–1891.
Published: 01 May 2013
... asymmetric cell division of interfollicular progenitor cells. Once induced, miR-203 rapidly promotes the cell cycle exit within 6 hours and abolishes self-renewal of the progenitor cells. With an inducible mouse model, we identify numerous miR-203 in vivo targets that are highly enriched in regulation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 459–470.
Published: 15 January 2013
...Marta Roccio; Daniel Schmitter; Marlen Knobloch; Yuya Okawa; Daniel Sage; Matthias P. Lutolf Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 56–65.
Published: 01 January 2013
.../STAT ligand Unpaired (Upd) and BMPs to maintain CySCs and GSCs, respectively. However, GSCs also require BMPs produced by CySCs, and as such CySCs are part of the niche for GSCs. Here we describe a role for another secreted ligand, Hedgehog (Hh), produced by niche cells, in the self-renewal of CySCs...
Includes: Supplementary data