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Keywords: Self-renewal
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev199901.
Published: 7 December 2021
... ABSTRACT Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the embryo uncertain. Here, we avoided using feeder...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev194399.
Published: 8 June 2021
... show that a self-renewing cell type – if defined as suggested by this framework – must reside at the top of any homeostatic renewing lineage hierarchy, and only there. This architecture arises as a natural consequence of homeostasis, and indeed is the only possible way that lineage architectures can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
.... , Smith , A. and Nichols , J. ( 2014 ). The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification . Nat. Cell Biol.   16 , 516 - 528 . 10.1038/ncb2965 Bradley , A. , Evans , M. , Kaufman , M. H. and Robertson...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev156059.
Published: 18 February 2019
..., are generated. Recent studies have significantly modified earlier views on the mechanisms of NSC self-renewal and neurogenesis in the adult brain. Here, we discuss the molecular control, heterogeneity, regional specification and cell division modes of V-SVZ NSCs, and draw comparisons with NSCs in the SGZ. We...
Journal Articles
Journal: Development
Development (2018) 145 (2): dev154534.
Published: 25 January 2018
...Caroline Dillard; Karine Narbonne-Reveau; Sophie Foppolo; Elodie Lanet; Cédric Maurange ABSTRACT Whether common principles regulate the self-renewing potential of neural stem cells (NSCs) throughout the developing central nervous system is still unclear. In the Drosophila ventral nerve cord...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 235–247.
Published: 15 January 2017
... for myogenic commitment and differentiation, timely repression of their activity is necessary for the self-renewal and maintenance of muscle stem cells (satellite cells). Here, we define Ascl2 as a novel inhibitor of MRFs. During mouse development, Ascl2 is transiently detected in a subpopulation of Pax7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4312–4323.
Published: 1 December 2016
...Xing Ma; Yingying Han; Xiaoqing Song; Trieu Do; Zhihao Yang; Jianquan Ni; Ting Xie Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell self-renewal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3097–3108.
Published: 1 September 2016
... that facilitates the membrane localization of GLP-1 /Notch. Self-renewal Differentiation STRIPAK Far complex Germ cells Next, we tested the effect of farl-11(kp35) on the phenotype of glp-1(q231) , which is a temperature-sensitive loss-of-function ( lf ) allele. Adults homozygous for glp-1(q231...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
...Jun Yu; Xiang Lan; Xia Chen; Chao Yu; Yiwen Xu; Yujuan Liu; Lingna Xu; Heng-Yu Fan; Chao Tong The homeostasis of self-renewal and differentiation in stem cells is controlled by intrinsic signals and their niche. We conducted a large-scale RNA interference (RNAi) screen in Drosophila testes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 575–581.
Published: 15 February 2016
... outcomes with regards to cell fate in each context. Asymmetric cell division Retina Cell lineage Oriented divisions Cell fate decision Stem cell Self-renewal Differentiation Whereas differential exposure to environmental cues can instruct asymmetric fates, varying mitotic spindle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1572–1581.
Published: 1 May 2015
... re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors...
Journal Articles
Journal: Development
Development (2015) 142 (7): 1228–1241.
Published: 1 April 2015
...Yuwen Li; Jiao Liu; Wencheng Li; Aaron Brown; Melody Baddoo; Marilyn Li; Thomas Carroll; Leif Oxburgh; Yumei Feng; Zubaida Saifudeen Contrary to its classic role in restraining cell proliferation, we demonstrate here a divergent function of p53 in the maintenance of self-renewal of the nephron...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 41–50.
Published: 1 January 2015
... goblet cell lineage that partially mimics Notch loss-of-function defects. Finally, we provide evidence that Bmi1 contributes to ISC self-renewal. Taken together, our results indicate that Notch signaling exerts a direct effect on the maintenance of ISCs that involves a direct cooperation with β-catenin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4697–4709.
Published: 15 December 2014
...Chen-yan Ma; Mao-jin Yao; Qi-wei Zhai; Jian-wei Jiao; Xiao-bing Yuan; Mu-ming Poo The balance between self-renewal and differentiation of adult neural stem cells (aNSCs) is essential for the maintenance of the aNSC reservoir and the continuous supply of new neurons, but how this balance is fine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4087–4097.
Published: 1 November 2014
...Sowmya Parameswaran; Xiaohuan Xia; Ganapati Hegde; Iqbal Ahmad In vertebrate retina, histogenesis occurs over an extended period. To sustain the temporal generation of diverse cell types, retinal progenitor cells (RPCs) must self-renew. However, self-renewal and regulation of RPCs remain poorly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1649–1659.
Published: 15 April 2014
... and differentiation of LRCs in vitro and impaired satellite cell self-renewal after muscle injury. By contrast, loss of p21 cip1 only affected nonLRCs, in which myogenic commitment was inhibited. Our results provide evidence that restriction of self-renewal potential to LRCs is established early in life...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4155–4164.
Published: 15 October 2013
... cell self-renewal and differentiation; they divide asymmetrically to self-renew and generate the neurons and glia of the CNS. Here we report the identification of midlife crisis ( mdlc ; CG4973 ) as a gene required for the maintenance of neuronal differentiation and for neuroblast proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3532–3540.
Published: 1 September 2013
...Xiankun Zeng; Xinhua Lin; Steven X. Hou The proportion of stem cells versus differentiated progeny is well balanced to maintain tissue homeostasis, which in turn depends on the balance of the different signaling pathways involved in stem cell self-renewal versus lineage-specific differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2525–2534.
Published: 15 June 2013
... ( luciano.dicroce@crg.eu ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Polycomb Stem cells Transcription Differentiation Self-renewal Although stem cells were discovered decades ago ( Till...
Journal Articles
Journal: Development
Development (2013) 140 (9): 1882–1891.
Published: 1 May 2013
... the asymmetric cell division of interfollicular progenitor cells. Once induced, miR-203 rapidly promotes the cell cycle exit within 6 hours and abolishes self-renewal of the progenitor cells. With an inducible mouse model, we identify numerous miR-203 in vivo targets that are highly enriched in regulation...
Includes: Supplementary data