... constraints pattern and shape the mammalian embryo. Morphogenesis Mechanobiology Self-organisation Embryogenesis Organoids Somitogenesis Neural tube Stem cells Gastruloids Stembryogenesis European Molecular Biology Laboratory http://dx.doi.org/10.13039/100013060 Agence...

.... , Cossy , A.-C. , Lutolf , M. P. , Duboule , D. and Arias , A. M. (2018). Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids . Nature 562 , 272 - 276 . 10.1038/s41586-018-0578-0 Bélisle , J. M. , Kunik , D. and Costantino , S...

... self-organisation may be initiated independently of the highly ordered tissue interactions that help to assemble the eye in vivo . These results help to explain how stem cell aggregates spontaneously self-organise into functional eye-cups in vitro . We anticipate these findings will help to underpin...

... of physical forces, and molecular and cellular mechanisms, in driving self-organisation and lineage formation that are shared between eutherian mammals. References Aiken , C. E. M. , Swoboda , P. P. L. , Skepper , J. N. and Johnson , M. H. (2004). The direct measurement...

... Micropatterning Self-organisation Stem cells Mouse Wellcome Trust 10.13039/100010269 WT103789AIA WT100133 Agence National de la Recherche 14-CE11-0012-01/STAR Developmental patterning is the process through which spatially defined regions of distinct cell types emerge from...

...James G. Lefevre; Han S. Chiu; Alexander N. Combes; Jessica M. Vanslambrouck; Ali Ju; Nicholas A. Hamilton; Melissa H. Little ABSTRACT Human pluripotent stem cells, after directed differentiation in vitro , can spontaneously generate complex tissues via self-organisation of the component cells...

... axial organisation. Here, we report that small aggregates of mESCs, of about 300 cells, self-organise into polarised structures that exhibit collective behaviours reminiscent of those that cells exhibit in early mouse embryos, including symmetry breaking, axial organisation, germ layer specification...

... recent examples in which embryonic stem cells can self-organise into three-dimensional structures – the optic cup and the pituitary epithelium; and one case of self-organising adult stem cells – the gut epithelium. We summarise how these approaches have revealed intrinsic programs that drive locally...