... Oscillation Pancreas Segmentation clock National Institutes of Health R35GM140805 Embryonic development proceeds as a cascade of spatiotemporal events. Although there has been much emphasis on understanding the spatial control of embryonic development, there is scant focus...

... oscillations linked to the segmentation clock are synchronized across cells in the presomitic mesoderm (PSM) and result in tissue-level wave patterns. To examine their onset during mouse embryo development, we studied the dynamics of the segmentation clock gene Lfng during gastrulation. To this end, we...

... in the signalling circuit that operates in the tail end that both sustains progenitors and drives maturation of the PSM into somites. Interfering with Myc function in the PSM, where it displays oscillatory expression, delays the timing of segmentation clock oscillations and thus of somite formation. In summary, we...

... within an individual and across species. Despite intense study of the segmentation clock governing the timing of somite generation, how it relates to somite size is poorly understood. Here, we examine somite scaling and find that somite size at specification scales with the length of the presomitic...

...Marina Matsumiya; Takehito Tomita; Kumiko Yoshioka-Kobayashi; Akihiro Isomura; Ryoichiro Kageyama ABSTRACT Somites are periodically formed by segmentation of the anterior parts of the presomitic mesoderm (PSM). In the mouse embryo, this periodicity is controlled by the segmentation clock gene Hes7...

...Dustin R. Williams; Emily T. Shifley; Kara M. Braunreiter; Susan E. Cole Vertebrate somitogenesis is regulated by a segmentation clock. Clock-linked genes exhibit cyclic expression, with a periodicity matching the rate of somite production. In mice, lunatic fringe ( Lfng ) expression oscillates...

...Nathan P. Shih; Paul François; Emilie A. Delaune; Sharon L. Amacher The formation of reiterated somites along the vertebrate body axis is controlled by the segmentation clock, a molecular oscillator expressed within presomitic mesoderm (PSM) cells. Although PSM cells oscillate autonomously...

...Ahmet Ay; Jack Holland; Adriana Sperlea; Gnanapackiam Sheela Devakanmalai; Stephan Knierer; Sebastian Sangervasi; Angel Stevenson; Ertuğrul M. Özbudak The vertebrate segmentation clock is a gene expression oscillator controlling rhythmic segmentation of the vertebral column during embryonic...

...Cristian Soza-Ried; Emre Öztürk; David Ish-Horowicz; Julian Lewis Formation of somites, the rudiments of vertebrate body segments, is an oscillatory process governed by a gene-expression oscillator, the segmentation clock. This operates in each cell of the presomitic mesoderm (PSM...

.... , Gossler A. , Kanzler B. , Herrmann B. G. ( 2003 ). Wnt3a plays a major role in the segmentation clock controlling somitogenesis . Dev. Cell 4 , 395 – 406 . Aulehla A. , Wiegraebe W. , Baubet V. , Wahl M. B. , Deng C. , Taketo M. , Lewandoski M...

...Ahmet Ay; Stephan Knierer; Adriana Sperlea; Jack Holland; Ertuğrul M. Özbudak Oscillations are prevalent in natural systems. A gene expression oscillator, called the segmentation clock, controls segmentation of precursors of the vertebral column. Genes belonging to the Hes/her family encode...

...Anja Hanisch; Maxine V. Holder; Suma Choorapoikayil; Martin Gajewski; Ertuǧrul M. Özbudak; Julian Lewis A gene expression oscillator called the segmentation clock controls somite segmentation in the vertebrate embryo. In zebrafish, the oscillatory transcriptional repressor genes her1 and her7...

... of Tribolium is based on a segmentation clock. Specifically, we show that the Tribolium primary pair-rule gene, Tc-even-skipped ( Tc-eve ), is expressed in waves propagating from the posterior pole and progressively slowing until they freeze into stripes; such dynamics are a hallmark of clock-based...

.... * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. 2012 Determination front Gastrulation Segmentation clock A characteristic feature...

...Anna Trofka; Jamie Schwendinger-Schreck; Tim Brend; William Pontius; Thierry Emonet; Scott A. Holley Using in vitro and in vivo assays, we define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock. Some of the dimers do not appear...

.... In vertebrates, segments are formed sequentially by a segmentation ‘clock’ of oscillating gene expression involving Notch pathway components. Recent studies in spiders and basal insects have suggested that segmentation in these arthropods also involves Notch-based signalling. These observations have been...

... for a long-standing puzzle regarding the functions of the two Delta proteins in the somite segmentation clock – an explanation that is based on the proposition that they associate heterophilically to activate Notch. Within cells that express both deltaC and deltaD , simultaneous detection of the two...

... is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken...

...Kana Ishimatsu; Atsuko Takamatsu; Hiroyuki Takeda The spatial and temporal periodicity of somite formation is controlled by the segmentation clock, in which numerous cells cyclically express hairy -related transcriptional repressors with a posterior-to-anterior phase delay, creating ‘traveling...

... of the segmentation clock. We next introduced this transgene into the Lfng -null genetic background to generate a Mesp2 Lfng/+ Lfng −/− mouse. The expression levels of Lfng in the Mesp2 locus were found to be low ( Fig. 6C,E ; see Fig. S5C in the supplementary material ), but we did observe...