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Keywords: Second heart field
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Journal Articles
In collection:
Cardiovascular development and regeneration
Journal:
Development
Development (2024) 151 (17): dev202895.
Published: 2 September 2024
..., leading to a short ventricle and outflow tract abnormalities. Heart development Second heart field Morphogenesis Congenital heart disease FGF signaling National Institutes of Health R35 HL135778 New York State Department of Health http://dx.doi.org/10.13039/100004856...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Journal:
Development
Development (2023) 150 (21): dev201677.
Published: 30 October 2023
... of Mef2c -AHF genetic lineage tracing (red) in control and Tbx20 EH1Mut embryos. Sections are co-stained with TPM1 (green). Data are mean±s.e.m. ** P ≤0.01 (Welch's t -test). aSHF, anterior second heart field; AT; atria; HT, heart tube; OFT, outflow tract; pSHF, posterior second heart field; RV, right...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Christopher J. Derrick, Eric J. G. Pollitt, Ashley Sanchez Sevilla Uruchurtu, Farah Hussein, Andrew J. Grierson, Emily S. Noël
Journal:
Development
Development (2021) 148 (20): dev199691.
Published: 22 October 2021
... simultaneously with growth of the heart. Cardiac growth during early heart morphogenesis is driven by deployment of cells from the second heart field (SHF) into both poles of the heart. Laminin is a core component of the extracellular matrix and, although mutations in laminin subunits are linked with cardiac...
Includes: Supplementary data
Journal Articles
Prashan De Zoysa, Jiang Liu, Omar Toubat, Jongkyu Choi, Anne Moon, Parkash S. Gill, Antonio Duarte, Henry M. Sucov, S. Ram Kumar
Journal:
Development
Development (2020) 147 (17): dev185249.
Published: 11 September 2020
..., is expressed by second heart field (SHF) progenitors at time-points that are crucial in SHF biology. Dll4-mediated Notch signaling is required for maintaining an adequate pool of SHF progenitors, such that Dll4 knockout results in a reduction in proliferation and an increase in apoptosis. A reduced SHF...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Andrew Holowiecki, Kelsey Linstrum, Padmapriyadarshini Ravisankar, Kashish Chetal, Nathan Salomonis, Joshua S. Waxman
Journal:
Development
Development (2020) 147 (5): dev185652.
Published: 2 March 2020
... of the later-differentiating outflow tract (OFT). We show that improper specification and proliferation of second heart field (SHF) progenitors in zebrafish lazarus ( lzr ) mutants, which lack the transcription factor Pbx4, produces enlarged hearts owing to an increase in ventricular and smooth muscle cells...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Journal:
Development
Development (2019) 146 (20): dev181719.
Published: 9 October 2019
...Ding Li; Allyson Angermeier; Jianbo Wang ABSTRACT The second heart field (SHF) harbors progenitors that are important for heart formation, but little is known about its morphogenesis. We show that SHF population in the mouse splanchnic mesoderm (SpM-SHF) undergoes polarized morphogenesis...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Natalie Gibb, Savo Lazic, Xuefei Yuan, Ashish R. Deshwar, Meaghan Leslie, Michael D. Wilson, Ian C. Scott
Journal:
Development
Development (2018) 145 (22): dev167510.
Published: 21 November 2018
... , C. E. and Burns , C. G. ( 2013 ). Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function . Development 140 , 1353 - 1363 . 10.1242/dev.088351 Hami , D. , Grimes , A. C. , Tsai , H.-J...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Sophie Colombo, Carmen de Sena-Tomás, Vanessa George, Andreas A. Werdich, Sunil Kapur, Calum A. MacRae, Kimara L. Targoff
Journal:
Development
Development (2018) 145 (3): dev161497.
Published: 5 February 2018
... transcription factor is a central regulator of cardiac development and is expressed in both the first and second heart fields (FHF and SHF). We have previously revealed essential functions of nkx2.5 and nkx2.7 , two Nkx2-5 homologs expressed in zebrafish cardiomyocytes, in maintaining ventricular identity...
Includes: Supplementary data
Journal Articles
In collection:
Cardiovascular development and regeneration
Noelle Paffett-Lugassy, Natasha Novikov, Spencer Jeffrey, Maryline Abrial, Burcu Guner-Ataman, Srinivasan Sakthivel, Caroline E. Burns, C. Geoffrey Burns
Journal:
Development
Development (2017) 144 (24): 4616–4624.
Published: 15 December 2017
...Noelle Paffett-Lugassy; Natasha Novikov; Spencer Jeffrey; Maryline Abrial; Burcu Guner-Ataman; Srinivasan Sakthivel; Caroline E. Burns; C. Geoffrey Burns During mammalian embryogenesis, cardiac progenitor cells constituting the second heart field (SHF) give rise to the right ventricle and primitive...
Includes: Supplementary data
Journal Articles
Leila Jahangiri, Michka Sharpe, Natasha Novikov, Juan Manuel González-Rosa, Asya Borikova, Kathleen Nevis, Noelle Paffett-Lugassy, Long Zhao, Meghan Adams, Burcu Guner-Ataman, Caroline E. Burns, C. Geoffrey Burns
Journal:
Development
Development (2016) 143 (1): 113–122.
Published: 1 January 2016
.... Initially, cardiomyocytes derived from first heart field (FHF) progenitors assemble the linear heart tube. Thereafter, second heart field (SHF) progenitors differentiate into cardiomyocytes that are accreted to the poles of the heart tube over a well-defined developmental window. Although heart tube...
Includes: Supplementary data
Journal Articles
Kerry M. Dorr, Nirav M. Amin, Lauren M. Kuchenbrod, Hanna Labiner, Marta S. Charpentier, Larysa H. Pevny, Andy Wessels, Frank L. Conlon
Journal:
Development
Development (2015) 142 (11): 2037–2047.
Published: 1 June 2015
... CASZ1 is expressed in murine cardiomyocytes. Genetic fate mapping with an inducible Casz1 allele demonstrates that CASZ1-expressing cells give rise to cardiomyocytes in the first and second heart fields. We show through the generation of a cardiac conditional null mutation that Casz1 is essential...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2015) 142 (10): 1767–1776.
Published: 15 May 2015
.... Published by The Company of Biologists Ltd 2015 SUMMARY: The study of zebrafish embryos deficient for Gpc4 reveals that it is essential for efficient cardiomyocyte differentiation, providing insights into how mutations in glypicans can cause congenital heart defects. Second heart field Wnt...
Includes: Supplementary data
Journal Articles
Wen Luo, Xia Zhao, Hengwei Jin, Lichan Tao, Jingai Zhu, Huijuan Wang, Brian A. Hemmings, Zhongzhou Yang
Journal:
Development
Development (2015) 142 (4): 732–742.
Published: 15 February 2015
...Wen Luo; Xia Zhao; Hengwei Jin; Lichan Tao; Jingai Zhu; Huijuan Wang; Brian A. Hemmings; Zhongzhou Yang Second heart field (SHF) progenitors exhibit continued proliferation and delayed differentiation, which are modulated by FGF4/8/10, BMP and canonical Wnt/β-catenin signaling. PTEN-Akt signaling...
Includes: Supplementary data
Journal Articles
Verónica Uribe, Claudio Badía-Careaga, Jesús C. Casanova, Jorge N. Domínguez, José Luis de la Pompa, Juan José Sanz-Ezquerro
Journal:
Development
Development (2014) 141 (21): 4168–4181.
Published: 1 November 2014
... show that Arid3b is expressed in the myocardium of the tubular heart and in second heart field progenitors. Arid3b -deficient embryos show cardiac abnormalities, including a notable shortening of the poles, absence of myocardial differentiation and altered patterning of the atrioventricular canal...
Includes: Supplementary data
Journal Articles
Yocheved L. Schindler, Kristina M. Garske, Jinhu Wang, Beth A. Firulli, Anthony B. Firulli, Kenneth D. Poss, Deborah Yelon
Journal:
Development
Development (2014) 141 (16): 3112–3122.
Published: 15 August 2014
.... Proliferation assays reveal that hand2 can impact cardiomyocyte production by promoting division of late-differentiating cardiac progenitors within the second heart field. Additionally, our data suggest that hand2 can influence cardiomyocyte production by altering the patterning of the anterior lateral plate...
Includes: Supplementary data
Journal Articles
Burcu Guner-Ataman, Noelle Paffett-Lugassy, Meghan S. Adams, Kathleen R. Nevis, Leila Jahangiri, Pablo Obregon, Kazu Kikuchi, Kenneth D. Poss, Caroline E. Burns, C. Geoffrey Burns
Journal:
Development
Development (2013) 140 (6): 1353–1363.
Published: 15 March 2013
...Burcu Guner-Ataman; Noelle Paffett-Lugassy; Meghan S. Adams; Kathleen R. Nevis; Leila Jahangiri; Pablo Obregon; Kazu Kikuchi; Kenneth D. Poss; Caroline E. Burns; C. Geoffrey Burns Second heart field (SHF) progenitors perform essential functions during mammalian cardiogenesis. We recently identified...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2011) 138 (11): 2389–2398.
Published: 1 June 2011
... located medially relative to atrial progenitors ( Schoenebeck et al., 2007 ). The portion of the heart field that gives rise to the initial heart tube has been called the first heart field, whereas the second heart field is added later. In mouse, these two populations of cardiac progenitors...
Includes: Supplementary data
Journal Articles
Fabienne Lescroart, Robert G. Kelly, Jean-François Le Garrec, Jean-François Nicolas, Sigolène M. Meilhac, Margaret Buckingham
Journal:
Development
Development (2010) 137 (19): 3269–3279.
Published: 1 October 2010
...Fabienne Lescroart; Robert G. Kelly; Jean-François Le Garrec; Jean-François Nicolas; Sigolène M. Meilhac; Margaret Buckingham Head muscle progenitors in pharyngeal mesoderm are present in close proximity to cells of the second heart field and show overlapping patterns of gene expression. However...
Includes: Supplementary data
Journal Articles
Andrew D. Hoffmann, Michael A. Peterson, Joshua M. Friedland-Little, Stuart A. Anderson, Ivan P. Moskowitz
Journal:
Development
Development (2009) 136 (10): 1761–1770.
Published: 15 May 2009
... that Hedgehog (Hh) signaling marked a subset of cardiac progenitors specific to the atrial septum and the pulmonary trunk in the mouse. Using genetic inducible fate mapping with Gli1 CreERT2 , we marked Hh-receiving progenitors in anterior and posterior second heart field splanchnic mesoderm between E8 and E10...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2009) 136 (9): 1465–1474.
Published: 1 May 2009
...Tessa Peterkin; Abigail Gibson; Roger Patient Over the past few years it has become clear that over half of the mammalian heart derives from outside the heart field as originally defined. Such a second heart field, however, has not been described in zebrafish, which could explain its smaller, two...
Includes: Supplementary data
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