... junctions are positioned at the future boundary of apical and basolateral domains. Polarity maintenance then involves complementary and antagonistic interplay between apical and basal polarity complexes. The Scribble/Dlg module is well-known for promoting basolateral identity during polarity maintenance...

...Zohreh Sharifkhodaei; Mary M. Gilbert; Vanessa J. Auld ABSTRACT Junctional complexes that mediate cell adhesion are key to epithelial integrity, cell division and permeability barrier formation. In Drosophila , the scaffolding proteins Scribble (Scrib) and Discs Large (Dlg) are key regulators...

... the systematic analysis of pattern formation, proliferation and growth in wild-type and scrib mutant wing imaginal discs: a neoplastic tumor model. Drosophila Wing imaginal discs Pattern formation Scribble Drosophila wing imaginal discs have been an important developmental model for study...

... asymmetrically and constitute an excellent paradigm for investigating this connection further. Here we show that the simultaneous loss of the asymmetric cell division regulators Canoe (afadin in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption...

... their leading edge (LE), which exhibits a breakdown in apicobasal polarity as adhesions are severed with the neighbouring amnioserosa cells. Studies using mammalian cells have demonstrated that Scribble (Scrib), an important determinant of apicobasal polarity that functions in a protein complex, controls...