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Keywords: Scleraxis
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev185389.
Published: 24 June 2020
... that statin, an inhibitor of the mevalonate pathway, and Rac GTPases regulate the poorly understood process of early tendon development. Tendon Scleraxis Chemical screen Statin Zebrafish Tendons and ligaments are key components of the musculoskeletal system, transmitting and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev186239.
Published: 12 May 2020
... mesenchymal cells towards pre-osteoblasts during sternum ossification at the boundary of the lateral and somitic mesoderm. Pre-osteoblast Sternum Fibroblast Runx2 Scleraxis Lateral plate mesenchyme cells The sternum protects the heart and lungs in vertebrates and constitutes the most...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev182782.
Published: 04 October 2019
...Alice H. Huang; Spencer S. Watson; Lingyan Wang; Brendon M. Baker; Haruhiko Akiyama; John V. Brigande; Ronen Schweitzer ABSTRACT The transcription factor scleraxis ( Scx ) is required for tendon development; however, the function of Scx is not fully understood. Although Scx is expressed by all...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev167882.
Published: 26 July 2019
... long bones in mice is coordinated by a patterning mechanism involving global and regional genetic regulation. Cartilage Patterning Morphology Superstructure Sox9 Scleraxis Modularity Gli3 Pbx Hox Mouse The vertebrate skeleton is composed of numerous bones, each displaying a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
... applied to achieve anatomical and ultimately functional variation during sesamoid bone development. Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et al., 2017...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3839–3851.
Published: 15 October 2016
... regulation . Mech. Dev.   122 , 573 - 585 . 10.1016/j.mod.2004.11.005 Brent , A. E. and Tabin , C. J. ( 2004 ). FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression . Development   131 , 3885 - 3896...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... functional tendons ( Hall, 2005 ). We therefore compared the timeline of tendon development with that of patella formation by studying the expression of scleraxis ( Scx ), a tendon-specific marker ( Schweitzer et al., 2001 ). Results showed that, at E13.5, only primordial tendon cells were seen, whereas the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 787–796.
Published: 15 February 2015
... scleraxis (Scx) and osterix (Osx) antagonistically regulate tensile force-responsive PDL fibrogenesis and osteogenesis. In the developing PDL, Scx was induced during tooth eruption and co-expressed with Osx. Scx was highly expressed in elongated fibroblastic cells aligned along collagen fibers, whereas Osx...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3683–3696.
Published: 01 October 2014
... identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis ( Scx ) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon cells during mouse limb development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 791–801.
Published: 01 March 2009
... order to identify the molecular mechanisms that control the differentiation of the visceral mesenchyme into SMCs in the vertebrate stomach, we developed microarrays to analyze the gene expression profiles of undifferentiated and differentiated avian stomachs. We identify Scleraxis , a basic-helix-loop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (14): 2697–2708.
Published: 15 July 2007
...Nicholas D. Murchison; Brian A. Price; David A. Conner; Douglas R. Keene; Eric N. Olson; Clifford J. Tabin; Ronen Schweitzer The scleraxis ( Scx ) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function, we produced a...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (6): 1305–1314.
Published: 15 March 2005
... extensively. By contrast,the interactions between cells from different regions within the somite are less well characterised. Here, we demonstrate that myotomally derived FGFs act through the MAPK signal transduction cascade and in particular, ERK1/2 to activate scleraxis expression in a population of...
Journal Articles
Journal: Development
Development (2005) 132 (3): 515–528.
Published: 01 February 2005
... correspondence (e-mail: tabin@genetics.med.harvard.edu ) 26 11 2004 ©2005. 2005 Somite Syndetome Sclerotome Myotome Tendon Scleraxis Myf5 Myod1 ( MyoD ) Sox5 Sox6 FGF Mouse The vertebrate axial musculoskeletal system emerges from somites -segmentally arranged, paired...
Journal Articles
Journal: Development
Development (2004) 131 (16): 3885–3896.
Published: 15 August 2004
...Ava E. Brent; Clifford J. Tabin During somite development, a fibroblast growth factor (FGF) signal secreted from the myotome induces formation of a scleraxis ( Scx )-expressing tendon progenitor population in the sclerotome, at the juncture between the future lineages of muscle and cartilage. While...
Journal Articles
Journal: Development
Development (2001) 128 (19): 3855–3866.
Published: 01 October 2001
...Ronen Schweitzer; Jay H. Chyung; Lewis C. Murtaugh; Ava E. Brent; Vicki Rosen; Eric N. Olson; Andrew Lassar; Clifford J. Tabin Little is known about the genesis and patterning of tendons and other connective tissues, mostly owing to the absence of early markers. We have found that Scleraxis, a bHLH...