...Robert Fledrich; Theresa Kungl; Klaus-Armin Nave; Ruth M. Stassart ABSTRACT During the development of the peripheral nervous system, axons and myelinating Schwann cells form a unique symbiotic unit, which is realized by a finely tuned network of molecular signals and reciprocal interactions...

... from a precursor pool, we find that the corresponding cell of the peripheral nervous system, the myelinating Schwann cell (mSC), does not turn over in the adult. However, following injury, all mSCs can dedifferentiate to the proliferating progenitor-like Schwann cells (SCs) that orchestrate...

... as well as modulating cytoskeleton function. Although APC is expressed by Schwann cells, the role that it plays in these cells and in the myelination of the peripheral nervous system (PNS) is unknown. Therefore, we used the Cre-lox approach to generate a mouse model in which APC expression is specifically...

...Thomas D. Glenn; William S. Talbot In peripheral nerves, Schwann cells form the myelin sheath, which allows the efficient propagation of action potentials along axons. The transcription factor Krox20 regulates the initiation of myelination in Schwann cells and is also required to maintain mature...

... plate Schwann cells Snail2 Sox9 Chick Mouse The neural crest (NC) is a highly suitable system for investigating mechanisms of lineage segregation during embryogenesis, owing to the variety of derivatives issued from an initially discrete progenitor population. These derivatives range from...

...Caterina Berti; Luca Bartesaghi; Monica Ghidinelli; Desirée Zambroni; Gianluca Figlia; Zu-Lin Chen; Angelo Quattrini; Lawrence Wrabetz; M. Laura Feltri Radial sorting allows the segregation of axons by a single Schwann cell (SC) and is a prerequisite for myelination during peripheral nerve...

...Fuzi Jin; Baoxia Dong; John Georgiou; Qiuhong Jiang; Jinyi Zhang; Arjun Bharioke; Frank Qiu; Silvia Lommel; M. Laura Feltri; Lawrence Wrabetz; John C. Roder; Joel Eyer; Xiequn Chen; Alan C. Peterson; Katherine A. Siminovitch Schwann cells elaborate myelin sheaths around axons by spirally wrapping...

...Shlomo Krispin; Erez Nitzan; Yachia Kassem; Chaya Kalcheim Colonization of trunk neural crest derivatives in avians follows a ventral to dorsal order beginning with sympathetic ganglia, Schwann cells, sensory ganglia and finally melanocytes. Continuous crest emigration underlies this process, which...

...Marlies Knipper; Christine Bandtlow; Lika Gestwa; Iris Köpschall; Karin Rohbock; Barbara Wiechers; Hans-Peter Zenner; Ulrike Zimmermann ABSTRACT All cranial nerves, as well as the VIII th nerve which invades the cochlea, have a proximal end in which myelin is formed by Schwann cells and a distal...

..., demonstrating that isoforms can take over specific functions in vivo. Type I neuregulin is required for generation of neural crest-derived neurons in cranial ganglia and for trabeculation of the heart ventricle, whereas type III neuregulin plays an important role in the early development of Schwann cells...

...M. Laura Feltri; Steven S. Scherer; Raffaello Nemni; John Kamholz; Helen Vogelbacker; Marion Oronzi Scott; Nicola Canal; Vito Quaranta; Lawrence Wrabetz ABSTRACT In developing and regenerating peripheral nerve, Schwann cells interact with axons and extracellular matrix in order to ensheath...

...L. C. Smith-Thomas; A. R. Johnson; J. W. Fawcett Amongst the many cell types that differentiate from migratory neural crest cells are the Schwann cells of the peripheral nervous system. While it has been demonstrated that Schwann cells will not fully differentiate unless in contact with neurons...

...K. R. Jessen; L. Morgan; H. J. S. Stewart; R. Mirsky ABSTRACT Immunohistochemical methods are used to investigate in detail the development and regulation of three proteins (217c(Ran-1),A5E3 and GFAP) specifically associated with adult non-myelin-forming Schwann cells in the rat sciatic nerve, from...

...Rhona Mirsky; Cathérine Dubois; Louise Morgan; Kristján R. Jessen ABSTRACT In the rat sciatic nerve, the relationship between Schwann cells, axons, the extracellular matrix and perineurial sheath cells undergoes extensive modification between embryo day 15 and the onset of myelination during...

...P. A. Eccleston; P. G. C. Bannerman; D. E. Pleasure; J. Winter; R. Mirsky; K. R. Jessen ABSTRACT Neuronal membranes from rat dorsal root ganglia provide a mitogenic signal to cultured Schwann cells and it has been suggested this is an important factor in regulating Schwann cell numbers during...

...L. C. Smith-Thomas; J. W. Fawcett ABSTRACT During embryonic development, neural crest cells differentiate into a wide variety of cell types including Schwann cells of the peripheral nervous system. In order to establish when neural crest cells first start to express a Schwann cell phenotype...

...Greg Lemke; Moses Chao The elaboration of myelin by Schwann cells is triggered by contact with appropriate peripheral axons. Among the most prominent features of this interaction is the activation and high-level expression of the genes encoding the major myelin proteins P 0 and Myelin Basic Protein...

... phenotypic traits, such as HNK-1 immunoreactivity, with neural-crest-derived Schwann cells, but are not necessarily identical to them. We argue that while they may help motor axons to exit the neural tube at the correct position, they are unlikely to guide axons beyond the immediate vicinity of the neural...

... muscle, Schwann cells and cartilage, two reagents were specific for subpopulations of blastemal cells. One of these latter antibodies, termed 22/18, has provided new evidence about the origin of blastemal cells from Schwann cells and myofibres, and also identifies blastemal cells whose division...