..., freshwater planarian Schmidtea mediterranea . Using an RNA-sequencing approach, we identified two classes of markers expressed in sequential fashion when new pigment cells are generated during regeneration or in response to pigment cell ablation. We also report roles for FOXF-1 and ETS-1 transcription...

... Migration Planarian Pluripotency Snail Wounding Schmidtea mediterranea Regeneration and tissue homeostasis in multicellular animals are a result of stem cell activity. Most animal adult life histories include some potential to regenerate tissues and organs but the efficiency and extent...

..., by modulating the canonical Notch pathway. Together, our results reveal a role for miR-124 in regulating the regeneration of a functional brain and visual system. Planarian Schmidtea mediterranea miR-124 Brain regeneration Photoreceptors Notch miRNA Fig. 2. Biophysical characterization...

...Sara Barberán; Susanna Fraguas; Francesc Cebrià The planarian Schmidtea mediterranea maintains and regenerates all its adult tissues through the proliferation and differentiation of a single population of pluripotent adult stem cells (ASCs) called neoblasts. Despite recent advances, the mechanisms...

...: The conserved JNK signalling pathway promotes Wnt signalling in stem cells to allow the regeneration of posterior structures in injured flatworms. Regeneration Stem cells JNK signalling Jun Wnt Planarian Schmidtea mediterranea Regenerative phenomena are widespread across the animal kingdom...

... Lophotrochozoan Planarians Schmidtea mediterranea In the field of developmental biology, much effort has been put towards understanding how stem and progenitor cells in an animal embryo produce the appropriate differentiated cell types in time and space to produce a functional organ. In order...

... declare no competing financial interests. 4 5 2013 12 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Basic helix-loop-helix Coe Single-minded Hes Neurogenesis Lophotrochozoan Planarians Regeneration Schmidtea mediterranea Stem...

... in any medium provided that the original work is properly attributed. Planaria Schmidtea mediterranea Regeneration Serotonergic neuron Pitx Islet1 Stem cell differentiation Transcription factors are key regulators of differentiation processes and the misexpression...

... of Schmidtea mediterranea . BMC Genomics 11 , 731 . Agata K. , Soejima Y. , Kato K. , Kobayashi C. , Umesono Y. , Watanabe K. ( 1998 ). Structure of the planarian central nervous system (CNS) revealed by neuronal cell markers . Zoolog. Sci. 15 , 433 – 440...

... no competing financial interests. 13 11 2012 © 2013. Published by The Company of Biologists Ltd H,K-ATPase Apoptosis Bioelectricity Morphogenesis Planaria Regeneration Size control Schmidtea mediterranea Numerous medically significant processes require...

... in the planarian Schmidtea mediterranea . RNA interference (RNAi) knockdown of a planarian ortholog of the axon-guidance receptor roundabout ( robo ) leads to unexpected phenotypes during anterior regeneration, including the development of a supernumerary pharynx (the feeding organ of the animal...

... a functional central nervous system (CNS) from almost any portion of their body, they are useful models in which to study the roles of guidance cues during neural regeneration. Here, we characterize two netrin homologs and one netrin receptor family member from Schmidtea mediterranea . RNAi analyses indicate...