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Keywords: Sav1
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Journal Articles

Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network

Zachary J. Brandt, Ashley E. Echert, Jonathan R. Bostrom, Paula N. North, Brian A. Link
Journal: Development
Development (2020) 147 (12): dev184242.
https://doi.org/10.1242/dev.184242
Published: 22 June 2020
... here a crucial role for Hippo-Yap/Taz signaling in this context. Analysis of sav1 mutant zebrafish revealed dysplastic morphology and expansion of both intrahepatic and extrahepatic biliary cells, and ultimately larval lethality. Biliary dysgenesis, but not larval lethality, is driven primarily by Yap...
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Includes: Supplementary data