... spatial and quantitative analysis of transcript patterns. Imaging Muscle stem cell Skeletal muscle Satellite cells Fluorescent in situ hybridization Mouse Skeletal myofibers are large multinucleated cells formed through the fusion of mononuclear myoblasts. Upon fusion, the cells...

.... , Tajbakhsh , S. , Kelly , R. G. , Wernig , A. , Buckingham , M. E. , Partridge , T. A. and Zammit , P. S. ( 2000 ). Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells . J. Cell Biol.   151 , 1221 - 1234 . 10.1083/jcb.151.6.1221...

... not abolish, embryonic and adult myogenesis. Raptor Rictor Protein synthesis Satellite cells Muscle regeneration Rapamycin Myogenesis is a tightly controlled process that results in the formation of skeletal muscle in several distinct myogenic waves. During development, mesodermal...

... of skeletal muscle largely depends on the expansion and differentiation of resident stem cells, the so-called satellite cells. Here, we demonstrate that postnatal satellite cells express components of the bone morphogenetic protein (BMP) signaling machinery. Overexpression of noggin in postnatal mice...

... a significantly smaller diameter than other fast fibers. In the same fibers, immunofluorescence staining for YAP/Taz and Tead1 was detected. Wnt/β-catenin signaling was absent in quiescent and activated satellite cells. Upon injury, Wnt/β-catenin signaling was detected in muscle fibers with centrally located...

..., but it was recently suggested that such recruitment is not obligatory: overload hypertrophy after synergist ablation of the plantaris muscle appeared normal in transgenic mice in which most of the satellite cells were abolished. When we essentially repeated these experiments analyzing the muscles...

... 3 mice, we investigated the function of H19 in adult muscle. Mutant muscles display hypertrophy and hyperplasia, with increased Igf2 and decreased myostatin ( Mstn ) expression. Many imprinted genes are expressed in muscle stem cells or satellite cells. Unexpectedly, the number of satellite cells...

...-ichiro Fukada Muscle satellite cells are indispensable for muscle regeneration, but the functional diversity of their daughter cells is unknown. Here, we show that many Pax7 + MyoD − cells locate both beneath and outside the basal lamina during myofiber maturation. A large majority of these Pax7 + MyoD...

...Frederic Relaix; Peter S. Zammit Following their discovery in 1961, it was speculated that satellite cells were dormant myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this accumulated over the years, until the link between satellite cells and the myoblasts...

...Weiyi Liu; Yefei Wen; Pengpeng Bi; Xinsheng Lai; X. Shawn Liu; Xiaoqi Liu; Shihuan Kuang Microenvironmental oxygen (O 2 ) regulates stem cell activity, and a hypoxic niche with low oxygen levels has been reported in multiple stem cell types. Satellite cells are muscle-resident stem cells...

... for their function. We have recently shown that adult skeletal muscle stem cells (satellite cells), once activated by isolation or injury, are a highly motile population with the potential to respond to multiple guidance cues, based on their expression of classical guidance receptors. We show here that, in vivo...

...So-ichiro Fukada; Masahiko Yamaguchi; Hiroki Kokubo; Ryo Ogawa; Akiyoshi Uezumi; Tomohiro Yoneda; Miroslav M. Matev; Norio Motohashi; Takahito Ito; Anna Zolkiewska; Randy L. Johnson; Yumiko Saga; Yuko Miyagoe-Suzuki; Kazutake Tsujikawa; Shin’ichi Takeda; Hiroshi Yamamoto Satellite cells, which...

...Malea M. Murphy; Jennifer A. Lawson; Sam J. Mathew; David A. Hutcheson; Gabrielle Kardon Muscle regeneration requires the coordinated interaction of multiple cell types. Satellite cells have been implicated as the primary stem cell responsible for regenerating muscle, yet the necessity...

... repair that is widely held to be accomplished by the satellite cells lying between the muscle fiber plasmalemma and the basement membrane. Cell transplantation and lineage-tracing studies have demonstrated that Pax7-expressing (Pax7 + ) satellite cells can repair damaged muscle tissue repeatedly after...

... for correspondence (e-mail: kalcheim@nn-shum.cc.huji.ac.il ) 8 12 2004 ©2005. 2005 Avian embryo Cell dissociation Desmin Epithelial-mesenchymal conversion Myotome PAX3 PAX7 Satellite cells Somite The somites are segmented structures that develop stepwise to give rise...

... the Cre-lox method. The results show that the spinal cord and the notochord regenerate from the same tissue type in the stump, with no labelling of other tissues. In the case of the muscle, we show that the myofibres of the regenerate arise from satellite cells and not from the pre-existing myofibres...

... Myogenesis Neural tube Somite Postmitotic cells Myoblast proliferation Satellite cells Studies addressing the development of the paraxial mesoderm have established that the epithelial somite can be subdivided into distinct domains according to the expression patterns of specific genes...

... but is maintained in satellite cells of adult muscles. FREK transcript is elevated upon addition of basic fibroblast growth factor to serum-starved satellite cells. From this sudy, we conclude: (1) that the structure and pattern of expression of FREK set it apart from other cloned fibroblast growth factor receptors...

...Timothy J. Hinterberger; Kate F. Barald ABSTRACT Muscle satellite cells are residual embryonic myoblast precursors responsible for muscle growth and regeneration. In order to examine the role of satellite cells in the initial events of muscle regeneration, we placed individual mature rat muscle...