... confirm previous findings with regards to functional specialization of some organs – the salivary gland and trachea – and clarify the embryonic functions of another – the plasmatocytes. We also identify two early developmental trajectories in germ cells and uncover a potential role for proteolysis during...

...Ayan T. Ray; Philippe Soriano ABSTRACT Loss of FGF signaling leads to defects in salivary gland branching, but the mechanisms underlying this phenotype remain largely unknown. We disrupted expression of Fgfr1 and Fgfr2 in salivary gland epithelial cells and found that both receptors function...

... at the cell surface. During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog) activates Rho1 signaling to drive apical constriction. The SG receptor that transduces the Fog signal into Rho1-dependent myosin activation has not been identified. Here, we reveal...

...Ninche Ninche; Mingyu Kwak; Soosan Ghazizadeh ABSTRACT Salivary glands exert exocrine secretory function to provide saliva for lubrication and protection of the oral cavity. Its epithelium consists of several differentiated cell types, including acinar, ductal and myoepithelial cells...

...Alison J. May; Noel Cruz-Pacheco; Elaine Emmerson; Eliza A. Gaylord; Kerstin Seidel; Sara Nathan; Marcus O. Muench; Ophir D. Klein; Sarah M. Knox ABSTRACT The ductal system of the salivary gland has long been postulated to be resistant to radiation-induced damage, a common side effect incurred...

...Melissa A. Metzler; Swetha Raja; Kelsey H. Elliott; Regina M. Friedl; Nhut Quang Huy Tran; Samantha A. Brugmann; Melinda Larsen; Lisa L. Sandell ABSTRACT In mammals, the epithelial tissues of major salivary glands generate saliva and drain it into the oral cavity. For submandibular salivary glands...

.... Endomitotic cells attain a higher ploidy and larger size than endocycling cells, and endomitotic SPG are necessary for the blood-brain barrier. Decreased Notch signaling promotes endomitosis even in the ventral nerve cord SPG that normally are mononucleate, but not in the endocycling salivary gland cells...

... signaling controls epithelial morphogenetic changes and differentiation using the salivary gland as a model. Experiments using genetically manipulated mice and organ cultures revealed that WNT signaling at an early stage (E12-E15) of submandibular salivary gland (SMG) development inhibits end bud...

.... 24 9 2013 10 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 Apicobasal polarity Epithelial organ development Salivary gland Tubulogenesis Drosophila Epithelial tissues in multicellular organisms are manifested by apicobasal polarity, which is essential...

... is known regarding how Fkh regulates tissue-specific gene expression. Here, we characterize Sage, a bHLH transcription factor expressed exclusively in the Drosophila salivary gland (SG). We show that Sage is required for late SG survival and normal tube morphology. We find that many Sage targets...

.... elegans GON-1, is required for cell migration during embryogenesis. AdamTS-A is expressed in multiple migratory cell types, including hemocytes, caudal visceral mesoderm (CVM), the visceral branch of the trachea (VBs) and the secretory portion of the salivary gland (SG). Loss of AdamTS-A causes defects...

..., we generated genetic models of the sole Drosophila melanogaster PI4KII gene. A specific requirement for PI4KII emerged in larval salivary glands. In PI4KII mutants, mucin-containing glue granules failed to reach normal size, with glue protein aberrantly accumulating in enlarged Rab7-positive late...

... and the basement membrane-mediated signals that regulate coordinated tissue organization are not well defined. Here, we report that Rho kinase (ROCK) controls coordinated tissue organization by restricting basement membrane to the epithelial basal periphery in developing mouse submandibular salivary glands...

... epithelial morphogenesis during glandular repair or regeneration. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 18 10 2011 © 2012. miR-200c Vldlr Salivary gland Mouse...

...Na Xu; Gaiana Bagumian; Michael Galiano; Monn Monn Myat Generation and maintenance of proper lumen size is important for tubular organ function. We report on a novel role for the Drosophila Rho1 GTPase in control of salivary gland lumen size through regulation of cell rearrangement, apical domain...

...Otso Häärä; Sayumi Fujimori; Ruth Schmidt-Ullrich; Christine Hartmann; Irma Thesleff; Marja L. Mikkola The developing submandibular salivary gland (SMG) is a well-studied model for tissue interactions and branching morphogenesis. Its development shares similar features with other ectodermal...

...Carolyn Pirraglia; Jenna Walters; Monn Monn Myat Generating and maintaining proper lumen size and shape in tubular organs is essential for organ function. Here, we demonstrate a novel role for p21-activated kinase 1 (Pak1) in defining the size and shape of the Drosophila embryonic salivary gland...

... manner, with the FGF signaling pathway to mediate the development of salivary glands. Fig. 6. Plexin A2 and plexin D1 are required for class 3 semaphorin-mediated cleft formation. ( A ) SMG cleft formation was reduced in the SMG ex vivo cultures treated with antisense ODNs against plexin A2...

...Katherine E. Harris; Steven K. Beckendorf Guided cell migration is necessary for the proper function and development of many tissues, one of which is the Drosophila embryonic salivary gland. Here we show that two distinct Wnt signaling pathways regulate salivary gland migration. Early in migration...

...), is required for the maturation of the ducts of the salivary gland and kidney. In the mouse, Cp2l1 is specifically expressed in the developing ducts of a number of exocrine glands, including the salivary gland, as well as in those of the kidney. In Cp2l1 -deficient mice, the expression of genes directly...