... RPE and ocular mesenchyme differentiation. Moreover, conditional inactivation followed by Geo-seq revealed that this differentiation program is dependent on the activity of SWI/SNF complexes, shown here to control the expression and activity of RPE transcription factors and, at the same time, inhibit...

... observed during distinct stages of gamete development, which include specific activities with critical meiotic functions. SWI/SNF chromatin remodelers are recognized regulators of gene transcription and DNA repair, but their composition and functions in meiosis are poorly understood. We have generated...

...Patric J. Ho; Sarah M. Lloyd; Xiaomin Bao ABSTRACT The BAF (SWI/SNF) chromatin remodeling complex plays a crucial role in modulating spatiotemporal gene expression during mammalian development. Although its remodeling activity was characterized in vitro decades ago, the complex actions of BAF...

... permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: The SWI/SNF protein Brg1 controls cell cycle length, cell cycle exit and cell survival, and is required for cell differentiation and retinal lamination...

.... In a screen for genes that regulate cell lineage determination in the posterior midgut, we identified that the Osa-containing SWI/SNF (Brahma) chromatin-remodeling complex regulates Drosophila midgut homeostasis. Mutations in subunits of the Osa-containing complex result in intestinal stem cell (ISC...

...-binding sites may serve as guideposts for identifying arterial-specific inhibitors of COUP-TFII , as we found BRG1 binding to be mostly similar in human arterial and venous endothelial cells. BRG1-containing SWI/SNF complexes exercise temporally and spatially specific control over target genes during...

... of the mammalian SWI/SNF chromatin-remodeling complex during spermatogenesis using a conditional allele of the ATPase subunit, brahma-related gene 1 ( Brg1 , or Smarca4 ). Not only do BRG1 levels peak during the early stages of meiosis, genetic ablation of Brg1 in murine embryonic gonocytes results in arrest...

...Courtney T. Griffin; Jennifer Brennan; Terry Magnuson ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin...

...Seongjin Seo; Genova A. Richardson; Kristen L. Kroll Chromatin remodeling complexes play crucial roles in transcription and are implicated in processes including cell proliferation, differentiation and embryonic patterning. Brg1 is the catalytic subunit of the SWI/SNF chromatin remodeling complex...

...Sara Farrona; Lidia Hurtado; John L. Bowman; José C. Reyes Chromatin remodeling is essential for the reprogramming of transcription associated with development and cell differentiation. The SWI/SNF complex was the first chromatin remodeling complex characterized in yeast and Drosophila...

... and Treisman, 2000 ),and E2F ( Staehling-Hampton et al., 1999 ). The Brm protein( Tamkun et al., 1992 ) is a SWI2/SNF2 family ATPase ( Eisen et al.,1995 ). Brm is a subunit of a large protein complex that is a member of the SWI/SNF family of chromatin remodeling complexes( Papoulas et al., 1998 ). Several...