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Journal Articles

H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells

Jiji T. Kurup, Zhijun Han, Wenfei Jin, Benjamin L. Kidder
Journal: Development
Development (2020) 147 (23): dev188516.
https://doi.org/10.1242/dev.188516
Published: 4 December 2020
... SUV420H2 regulates embryonic stem (ES) cell fate by patterning the epigenetic landscape. Here, we report that depletion of SUV420H2 leads to a near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES cell differentiation. SUV420H2-bound regions are enriched with repetitive...
View article titled, H4K20me3 methyltransferase <span class="search-highlight">SUV420H2</span> shapes the chromatin landscape of pluripotent embryonic stem cells
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Includes: Supplementary data