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Keywords: STAT
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Journal Articles
Journal: Development
Development (2017) 144 (11): 1937–1947.
Published: 1 June 2017
... characterised EC shapes and their dynamic changes. We show that germ cell encapsulation by ECs is a communal phenomenon, whereby EC-EC contacts stabilise an extensive meshwork of protrusions. We further show that Signal Transducer and Activator of Transcription (Stat) and Epidermal Growth Factor Receptor (Egfr...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4524–4535.
Published: 15 December 2012
... of Jak/Stat signaling in ISCs. Crucially, knocking down Jak/Stat or Spitz/Egfr signaling suppresses Apc1 -dependent ISC hyperproliferation. In summary, our results uncover a novel non-cell-autonomous interplay between Wnt/Myc, Egfr and Jak/Stat signaling in the regulation of intestinal hyperproliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (7): 1347–1353.
Published: 1 April 2008
... localisation of STATc. Treatment of cells with DIF-1 or exposure to hyper-osmotic stress induces a decrease in biochemically assayable PTP3 activity and both agents also induce serine-threonine phosphorylation of PTP3. These observations suggest a novel mode of STAT activation, whereby serine-threonine...
Journal Articles
Journal: Development
Development (2006) 133 (23): 4721–4729.
Published: 1 December 2006
.... In the Drosophila eye imaginal disc, Wingless (Wg) signaling defines the region that gives rise to head tissue. JAK/STAT signaling was thought to regulate growth of the eye disc but not pattern formation. However, we show that the JAK/STAT pathway plays an important role in patterning the eye disc:it promotes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3483–3492.
Published: 1 August 2005
...Debra L. Silver; Erika R. Geisbrecht; Denise J. Montell The evolutionarily conserved JAK/STAT signaling pathway is essential for the proliferation, survival and differentiation of many cells including cancer cells. Recent studies have implicated this transcriptional pathway in the process of cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (18): 4241–4248.
Published: 15 September 2002
...Willis X. Li; Herve Agaisse; Bernard Mathey-Prevot; Norbert Perrimon Malignant transformation frequently involves aberrant signaling from receptor tyrosine kinases (RTKs). These receptors commonly activate Ras/Raf/MEK/MAPK signaling but when overactivated can also induce the JAK/STAT pathway...