... by The Company of Biologists Ltd Hh Smo Upd JAK/STAT Cyst stem cell (CySC) Germline stem cell (GSC) Hub Niche Testis Self-renewal Drosophila has proven a useful model system in the study of stem cell biology, particularly in identifying the importance of the physical...

...Qing Shi; Shuang Li; Jianhang Jia; Jin Jiang Hedgehog (Hh) transduces signal by regulating the subcellular localization and conformational state of the GPCR-like protein Smoothened (Smo) but how Smo relays the signal to cytoplasmic signaling components remains poorly understood. Here, we show...

.... and Scott, M. P. ( 1999 ). Mouse patched1 controls body size determination and limb patterning. Development 126 , 4431 -4440. Moraes, R. C., Zhang, X., Harrington, N., Fung, J. Y., Wu, M. F., Hilsenbeck, S. G., Allred, D. C. and Lewis, M. T. ( 2007 ). Constitutive activation of smoothened (Smo...

... or other essential components of the Shh signaling pathway. Using Cre/ loxP -mediated tissue-specific inactivation of the smoothened ( Smo ) gene in the developing palatal mesenchyme, we show that the epithelially expressed Shh signals directly to the palatal mesenchyme to regulate palatal mesenchyme cell...

...Hongge Jia; Yajuan Liu; Wei Yan; Jianhang Jia The seven-transmembrane protein Smoothened (Smo) and Zn-finger transcription factor Ci/Gli are crucial components in Hedgehog (Hh) signal transduction that mediates a variety of processes in animal development. In Drosophila , multiple kinases have been...

... have genetically manipulated smoothened ( Smo ), which encodes a transmembrane protein that is essential for transducing all Hedgehog (Hh) signals. Removal of Smo from perichondrial cells by the Cre-LoxP approach prevents formation of a normal bone collar and also abolishes development of the primary...

...Fanxin Long; Xiaoyan M. Zhang; Seth Karp; Yingzi Yang; Andrew P. McMahon Indian hedgehog (Ihh), one of the three mammalian hedgehog (Hh) proteins, coordinates proliferation and differentiation of chondrocytes during endochondral bone development. Smoothened (Smo) is a transmembrane protein...

... during MF progression, we have analyzed the effects of clones simultaneously mutant for Mad 1-2 and smo 3 on photoreceptor development during stages following MF initiation. In contrast to single mutant Mad 1-2 or smo 3 clones, the doubly mutant clones block MF progression, suggesting...