... that inhibitory SMAD6 functions in endothelial cells to negatively regulate ALK1-mediated responses, and it is required to prevent vessel dysmorphogenesis and hemorrhage in the embryonic liver vasculature. Reduced Alk1 gene dosage rescued embryonic hepatic hemorrhage and microvascular capillarization induced...

... signaling of bone morphogenetic proteins (BMP) in these cells. Overexpression of inhibitory human SMAD6 ( huSMAD6 ) in limb MPCs abrogated BMP signaling, impaired their migration and proliferation, and accelerated myogenic lineage progression. Fewer primary myofibers developed, causing an aberrant...

... FGF functions as a conserved initiator of neural specification among chordates. * Author for correspondence (e-mail: [email protected] ) 11 11 2004 ©2005. 2005 Xenopus Vertebrates Chordates Neural induction FGF BMP SMAD6 eFGF Spemann's organiser Mesoderm...

... antagonist Smad6, either alone or together with a dominant-negative BMP receptor, Chordin and/or Noggin in competent epiblast is not sufficient to induce expression of Sox2 directly, even in combination with FGF2,FGF3, FGF4 or FGF8 and/or antagonists of Wnt signalling. These results strongly suggest that BMP...