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Keywords: SIX1
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Journal Articles
Journal: Development
Development (2023) 150 (14): dev201509.
Published: 13 July 2023
... checkpoint that defines myogenic commitment could improve hPSC differentiation to skeletal muscle. Analysis of several myogenic factors in human embryos and early hPSC differentiations found SIX1 + PAX3 + co-expression was most indictive of myogenesis. Using dCas9-KRAB hPSCs, we demonstrate that early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (9): dev200903.
Published: 3 May 2023
... embryonic development. We showed recently that the SIX1 homeoprotein, an essential regulator of organogenesis, is also a repressor of adult cellular senescence. Alterations in the SIX/EYA pathway are linked to the human branchio-oto-renal (BOR) syndrome, a rare congenital disorder associated with defects...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (1): dev177022.
Published: 3 January 2020
... taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro . Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev171421.
Published: 15 May 2019
.../j.ydbio.2017.03.004 Bessarab , D. A. , Chong , S.-W. and Korzh , V. ( 2004 ). Expression of zebrafish six1 during sensory organ development and myogenesis . Dev. Dyn.   230 , 781 - 786 . 10.1002/dvdy.20093 Bessarab , D. A. , Chong , S.-W. , Srinivas , B. P...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (5): 755–765.
Published: 1 March 2010
...Xuguang Nie; Jianbo Sun; Ronald E. Gordon; Chen-Leng Cai; Pin-Xian Xu Dysfunction of the ureter often leads to urine flow impairment from the kidney to the bladder, causing dilation of the ureter and/or renal pelvis. Six1 is a crucial regulator of renal development: mutations in human SIX1 cause...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (22): 5561–5572.
Published: 15 November 2004
...Dan Zou; Derek Silvius; Bernd Fritzsch; Pin-Xian Xu Eya1 encodes a transcriptional co-activator and is expressed in cranial sensory placodes. It interacts with and functions upstream of the homeobox gene Six1 during otic placodal development. Here, we have examined their role in cranial sensory...
Journal Articles
Journal: Development
Development (2004) 131 (3): 551–562.
Published: 1 February 2004
...Hidenori Ozaki; Kazuaki Nakamura; Jun-ichi Funahashi; Keiko Ikeda; Gen Yamada; Hisashi Tokano; Hiro-oki Okamura; Ken Kitamura; Shigeaki Muto; Hayato Kotaki; Katsuko Sudo; Reiko Horai; Yoichiro Iwakura; Kiyoshi Kawakami Six1 is a member of the Six family homeobox genes, which function as components...
Journal Articles
Journal: Development
Development (2003) 130 (17): 3989–4000.
Published: 1 September 2003
... report that Six1 is required for mouse auditory system development. During inner ear development, Six1 expression was first detected in the ventral region of the otic pit and later is restricted to the middle and ventral otic vesicle within which, respectively, the vestibular and auditory epithelia form...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3085–3094.
Published: 15 July 2003
...Pin-Xian Xu; Weiming Zheng; Li Huang; Pascal Maire; Christine Laclef; Derek Silvius The murine Six gene family, homologous to Drosophila sine oculis ( so ) which encodes a homeodomain transcription factor, is composed of six members ( Six1-6 ). Among the six members, only the Six2 gene has been...
Journal Articles
Journal: Development
Development (2002) 129 (13): 3033–3044.
Published: 1 July 2002
... hypoplasia, with severe reduction in the number of parafollicular cells and the size of the thyroid lobes and lack of fusion between the ultimobranchial bodies and the thyroid lobe. These data indicate that Eya1 also regulates mature thyroid gland formation. Furthermore, we show that Six1 expression...