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Keywords: SCF
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Journal Articles
Journal: Development
Development (2014) 141 (15): 2984–2992.
Published: 01 August 2014
..., which induces a microtubule reorganisation that localises bicoid and oskar mRNAs. Here we show that oocyte polarity requires Slmb, the substrate specificity subunit of the SCF E3 ubiquitin ligase that targets proteins for degradation. The Par-6/aPKC complex is ectopically localised to the posterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (10): 1679–1688.
Published: 15 May 2010
.... Nutcracker interacts through its F-box domain with members of a Cullin-1-based ubiquitin ligase complex (SCF): Cullin-1 and SkpA. This ubiquitin ligase does not regulate the stability of the caspase inhibitors DIAP1 and DIAP2, but physically binds Bruce, a BIR-containing giant protein involved in apoptosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (3): 559–568.
Published: 01 February 2006
... as `ubiquitinopathies'. Cullin-1 SCF Neural crest β-catenin Ubiquitin Protein degradation Xenopus During embryonic development the molecular profile of a cell has to be regulated in order to achieve cell specialisation. A large proportion of this regulation is carried out at the transcriptional...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6339–6349.
Published: 22 December 2003
..., Cyclin A persists longer than in wild type. In addition, Cyclin E expression is not downregulated after the fourth mitosis and accumulates in a polyubiquitinated form. Mutations in genes coding for components of the SCF pathway such as cul1, UbcD2 and effete enhance the extra division phenotype of encore...