... knockout of the stem cell factor Sall4 in mice by TCre caused tail truncation and a disorganized axial skeleton posterior to the lumbar level. Based on this phenotype, we hypothesized that, in addition to the previously reported role of Sall4 in neuromesodermal progenitors, Sall4 is involved...

...Wataru Katano; Shunta Mori; Shun Sasaki; Yuki Tajika; Koichi Tomita; Jun K. Takeuchi; Kazuko Koshiba-Takeuchi ABSTRACT Sall1 and Sall4 (Sall1/4), zinc-finger transcription factors, are expressed in the progenitors of the second heart field (SHF) and in cardiomyocytes during the early stages...

... and paraxial mesodermal progenitors in the trunk and tail during vertebrate body elongation. We show that Sall4 , a pluripotency-related transcription factor gene, has multiple roles in regulating NMPs and their descendants in post-gastrulation mouse embryos. Sall4 deletion using TCre caused body/tail...

...Anzy Miller; Meryem Ralser; Susan L. Kloet; Remco Loos; Ryuichi Nishinakamura; Paul Bertone; Michiel Vermeulen; Brian Hendrich Sall4 is an essential transcription factor for early mammalian development and is frequently overexpressed in cancer. Although it is reported to play an important role...

.... The transcription factors Sal-like 4 (SALL4) and promyelocytic leukemia zinc finger (PLZF; also known as ZBTB16) are known to be required for normal SSC function, but their targets are largely unknown. ChIP-seq in mouse THY1 + spermatogonia identified 4176 PLZF-bound and 2696 SALL4-bound genes, including 1149...

... through the Fgf, retinoic acid (RA) and Wnt/β-catenin pathways is necessary and sufficient to induce posterior fates in the neural plate, yet a mechanistic understanding of the process is lacking. Here, we screened for factors enriched in posterior neural tissue and identify spalt-like 4 ( sall4 ), which...

...Meyer Barembaum; Marianne Bronner-Fraser Vertebrate placodes are regions of thickened head ectoderm that contribute to paired sensory organs and cranial ganglia. We demonstrate that the transcription factor S palt4 (also known as Sall4 ) is broadly expressed in chick preplacodal epiblast and later...

...Masayo Sakaki-Yumoto; Chiyoko Kobayashi; Akira Sato; Sayoko Fujimura; Yuko Matsumoto; Minoru Takasato; Tatsuhiko Kodama; Hiroyuki Aburatani; Makoto Asashima; Nobuaki Yoshida; Ryuichi Nishinakamura Mutations in SALL4 , the human homolog of the Drosophila homeotic gene spalt ( sal ), cause...

...Steven A. Harvey; Malcolm P. O. Logan Okihiro syndrome (OS) is defined by forelimb defects associated with the eye disorder Duane anomaly and results from mutations in the gene SALL4. Forelimb defects in individuals with OS range from subtle thumb abnormalities to truncated limbs. Mutations...