...Wataru Katano; Shunta Mori; Shun Sasaki; Yuki Tajika; Koichi Tomita; Jun K. Takeuchi; Kazuko Koshiba-Takeuchi ABSTRACT Sall1 and Sall4 (Sall1/4), zinc-finger transcription factors, are expressed in the progenitors of the second heart field (SHF) and in cardiomyocytes during the early stages...

... and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing integrative analyses of epigenetic and transcriptional data in mole and mouse, we identified the co-option of SALL1...

... progenitor to renal vesicle are not well understood. Here, we show that Sall1interacts with the nucleosome remodeling and deacetylase complex (NuRD) to inhibit premature differentiation of nephron progenitor cells. Disruption of Sall1-NuRD in vivo in knock-in mice (Δ SRM ) resulted in accelerated...

... of the progenitor cell pool and differentiation of these cells into nephron precursor structures (renal vesicles) are not well understood. Here we show that Sall1, a nuclear transcription factor, is required to maintain the stemness of nephron progenitor cells. Transcriptional profiling of Sall1 mutant cells...

... expression in the tip compared with the stalk and are influenced by mesenchymal signals. The metanephric mesenchyme-derived signals that control gene expression at the ureteric bud tip are not well understood. In mouse Sall1 mutants, the ureteric bud grows out and invades the metanephric mesenchyme...

... similar, in fact, individuals with mutations in SALL4 have in some cases previously been diagnosed with HOS. Using zebrafish as a model, we have investigated the function of sall4 and the relationship between sall4 and tbx5 , during forelimb development. We demonstrate that sall4 and a related gene sall1...

... and renal tubules. We found that only cells strongly expressing Sall1 (Sall1-GFP high cells), a zinc-finger nuclear factor essential for kidney development, form colonies, and that they reconstitute a three-dimensional kidney structure in an organ culture setting. We also found that Rac- and JNK-dependent...

... of the mesenchyme. These results indicate that Six1 plays an essential role in early kidney development. In Six1 -/- kidney development, we have found that Pax2, Six2 and Sall1 expression was markedly reduced in the metanephric mesenchyme at E10.5,indicating that Six1 is required for the expression of these genes...

...Ryuichi Nishinakamura; Yuko Matsumoto; Kazuki Nakao; Kenji Nakamura; Akira Sato; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Sheila Scully; David L. Lacey; Motoya Katsuki; Makoto Asashima; Takashi Yokota SALL1 is a mammalian homolog of the Drosophila region-specific homeotic gene spalt...