... but led to sternum ossification defects as a result of defective generation of Runx2 + pre-osteoblasts. Conditional and temporal Ebf3 knockout mice revealed requirements of Ebf3 in the lateral plate mesenchyme cells (LPMs), especially in tendon/muscle connective tissue cells, and a stage-specific Ebf3...

... for proliferation in osteoprogenitors. In contrast, Taz is expressed in more-committed Runx2-expressing osteoblasts, Taz does not regulate osteoblast proliferation and Taz-Tead activity is unaffected in Dchs1 / Fat4 mutants. Finally, we show that Yap and Taz differentially regulate the transcriptional activity...

... signaling negatively regulated sequential tooth formation, an effect partly mediated by Bmp4. Runx2 , a gene whose loss-of-function mutations result in sequential formation of supernumerary teeth in the human cleidocranial dysplasia syndrome, suppressed the expression of Wnt inhibitors Axin2 and Drapc1...

...Takeshi Takarada; Ryota Nakazato; Azusa Tsuchikane; Koichi Fujikawa; Takashi Iezaki; Yukio Yoneda; Eiichi Hinoi Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation and its haploinsufficiency leads to cleidocranial dysplasia because...

... interests statement The authors declare no competing financial interests. 18 12 2009 © 2010. 2010 Collagen X BAC Transgenic Vegfa Runx2 Mmp13 Mouse Replacement of cartilage by bony tissue in the foetal growth plate of long bones, ribs and vertebrae, in a process...

... that has been converted into a transcriptional activator conversely accelerates chondrocyte maturation. Nkx3.2 represses expression of the chondrocyte maturation factor Runx2, and Runx2 misexpression can rescue the Nkx3.2-induced blockade of chondrocyte maturation. Taken together, these results suggest...