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Keywords: Runx2
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Journal Articles
Journal: Development
Development (2020) 147 (9): dev186239.
Published: 12 May 2020
... but led to sternum ossification defects as a result of defective generation of Runx2 + pre-osteoblasts. Conditional and temporal Ebf3 knockout mice revealed requirements of Ebf3 in the lateral plate mesenchyme cells (LPMs), especially in tendon/muscle connective tissue cells, and a stage-specific Ebf3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176776.
Published: 29 July 2019
... for proliferation in osteoprogenitors. In contrast, Taz is expressed in more-committed Runx2-expressing osteoblasts, Taz does not regulate osteoblast proliferation and Taz-Tead activity is unaffected in Dchs1 / Fat4 mutants. Finally, we show that Yap and Taz differentially regulate the transcriptional activity...
Journal Articles
Journal: Development
Development (2018) 145 (4): dev158048.
Published: 21 February 2018
... signaling negatively regulated sequential tooth formation, an effect partly mediated by Bmp4. Runx2 , a gene whose loss-of-function mutations result in sequential formation of supernumerary teeth in the human cleidocranial dysplasia syndrome, suppressed the expression of Wnt inhibitors Axin2 and Drapc1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 211–218.
Published: 15 January 2016
...Takeshi Takarada; Ryota Nakazato; Azusa Tsuchikane; Koichi Fujikawa; Takashi Iezaki; Yukio Yoneda; Eiichi Hinoi Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation and its haploinsufficiency leads to cleidocranial dysplasia because...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 901–911.
Published: 15 March 2010
... interests statement The authors declare no competing financial interests. 18 12 2009 © 2010. 2010 Collagen X BAC Transgenic Vegfa Runx2 Mmp13 Mouse Replacement of cartilage by bony tissue in the foetal growth plate of long bones, ribs and vertebrae, in a process...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 651–662.
Published: 15 February 2006
... that has been converted into a transcriptional activator conversely accelerates chondrocyte maturation. Nkx3.2 represses expression of the chondrocyte maturation factor Runx2, and Runx2 misexpression can rescue the Nkx3.2-induced blockade of chondrocyte maturation. Taken together, these results suggest...