..., quantitative, sensitive, versatile, robust . Development 145 , dev165753 . 10.1242/dev.165753 De Robertis , E. M. ( 2009 ). Spemann's organizer and the self-regulation of embryonic fields . Mech. Dev. 126 , 925 - 941 . 10.1016/j.mod.2009.08.004 Dray , N. , Lawton...

... is an improved understanding of the guiding principles of GRN evolution ( Peter and Davidson, 2011 ; Rebeiz et al., 2015 ; Halfon, 2017 ). It is likely that DSD often occurs in developmental GRNs that are robust to genetic change. The robustness of a GRN is a dynamical property that depends not just on network...

... Mathematical modelling Morphogenesis Noise Robustness Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 PID2021-122930NB-I00 CNS2022-135397 Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 CEX2020-001084-M The fine...

...Clément Dubois; Shivam Gupta; Andrew Mugler; Marie-Anne Félix ABSTRACT Few studies have measured the robustness to perturbations of the final position of a long-range migrating cell. In the nematode Caenorhabditis elegans , the QR neuroblast migrates anteriorly, while undergoing three division...

...Katarzyna Modzelewska; Louise Brown; Joseph Culotti; Nadeem Moghal ABSTRACT Long-term survival of an animal species depends on development being robust to environmental variations and climate changes. We used C. elegans to study how mechanisms that sense environmental changes trigger adaptive...

...Pascal F. Hagolani; Roland Zimm; Miquel Marin-Riera; Isaac Salazar-Ciudad ABSTRACT Embryonic development involves gene networks, extracellular signaling, cell behaviors (cell division, adhesion, etc.) and mechanical interactions. How should these be coordinated to lead to complex and robust...

...Kazunori Yamamoto; Akatsuki Kimura During early embryogenesis in animals, cells are arranged into a species-specific pattern in a robust manner. Diverse cell arrangement patterns are observed, even among close relatives. In the present study, we evaluated the mechanisms by which the diversity...

... in the Drosophila eye disc. We find that the area growth rate declines inversely proportional to the increasing total eye disc area. We identify two growth laws that are consistent with the growth data and that would explain the extraordinary robustness and evolutionary plasticity of the growth process and thus...