... fate maintenance and cancer. However, analysis of the roles of PcG proteins in orchestrating vertebrate developmental programs in vivo has been hampered by the early embryonic lethality of several PcG gene knockouts in mice. Here, we demonstrate that zebrafish Ring1b, the E3 ligase in Polycomb...

..., composition or amino acid sequences of the proteins in a PRC1-like complex are sufficiently divergent to make recognizing them difficult. Here we describe the genes mig - 32 and spat - 3 , which encode homologs of the human PRC1 core components Bmi-1 and Ring1B, respectively. Consistent with MIG-32...

... that maintain the state of transcriptional repression of several genes with relevance to development and in cell proliferation. We have identified Ring1B, the product of the Ring1B gene ( Rnf2 – Mouse Genome Informatics), by means of its interaction with the Polycomb group protein Mel18. We describe biochemical...

... Polycomb Mouse Ring1A Ring1B Hox Axial skeleton The Polycomb group ( Pc G) of genes were first identified as trans -acting regulators of homeotic gene function in Drosophila ( Kennison, 1995 ). Two clusters of homeotic genes, the Antennapedia complex (ANT-C) and the bithorax complex (BX-C...