... by the intramembrane protease Rhomboid. Some of the Drosophila Rhomboids also reside in the ER, where they attenuate signaling by premature cleavage of Star. The genome of the flour beetle Tribolium castaneum contains a single gene for each of the ligand-processing components, providing an opportunity to assess...

... are distinct; their actions are separated in time and have different effects on eggshell morphology. * Author for correspondence( stas@princeton.edu ) 25 6 2009 © 2009. © 2009. 2009 Feedback Feedforward EGFR Argos Sprouty Kekkon-1 Rhomboid Pattern formation Oogenesis...

... in the DA number is observed among Drosophila species; D. melanogaster has two DAs and D. virilis has four. Diversification in the expression pattern of rhomboid ( rho ), which activates EGFR signaling in somatic follicle cells, could cause the evolutionary divergence of DA numbers. Here we identified a cis...

... in apoptosis of smooth-cuticle cells between stages 12 and 14, bringing adjacent denticle regions together to result in denticle belt fusions by stage 15. Multiple factors stimulate EGFR signalling to promote smooth-cuticle cell survival: in addition to the spitz group genes,Rhomboid-3/roughoid...

.... and Gelbart, W. M. ( 1996 ). The TGF-β signaling pathway is essential for Drosophila oogenesis. Development 122 , 1555 -1565. Urban, S., Lee, J. R. and Freeman, M. ( 2001 ). Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107 , 173 -182. Vincent, S...

... and intervein cells in the Drosophila wing. The data presented here indicate that two distinct events are involved in the determination and differentiation of wing cells. (1) The establishment of a positive feedback amplification loop, which drives DER signaling in larval stages. At this time, rhomboid (rho...

... gene rhomboid. One model of this process is that boundaries of gene expression regulated by hedgehog or decapentaplegic provide reference points where rhomboid transcription is activated. We present an analysis of the gene plexus , whose loss of function causes an excess vein phenotype. Molecular...

..., Egfr encodes the Drosophila EGF-Receptor, spitz ( spi ) and vein ( vn ) encode EGF-related ligands, and rhomboid ( rho ) and Star ( S ) encode membrane proteins. In this study, we show that rho -mediated hyperactivation of the EGFR/MAPK pathway is required for vein formation throughout late larval...

...-dependent structures. The Hox genes Ultrabithorax and abdominal-A are required to activate an early stripe of Serrate transcription in abdominal segments. In the abdominal epidermis, Serrate promotes denticle diversity by precisely localizing a single cell stripe of rhomboid expression, which generates...

... incompletus spalt rhomboid Drosophila melanogaster An exquisite example of linear gene activation is the initiation of sim expression in a single row of mesectodermal cells abutting the snail expression domain in the mesoderm of blastoderm embryos ( Fig. 6B , right; Thomas et al., 1988...

... 9 1998 © 1998 by Company of Biologists 1998 Drosophila Wing vein Paravein Boundaries Lateral inhibition rhomboid hedgehog According to our preferred model, boundaries in third instar wing discs induce gene expression in narrow vein primordia, which produce short...

... the capacity of the pathway to pattern all follicle cells except the ventral-most rows. This may provide the spatial coordinates for the ventral-most follicle cell fates. A second group of target genes (e.g. rhomboid ( rho )) is induced only at later stages of oogenesis, and may require additional inputs...

... the Ras1-MAP kinase pathway. Localized activation of DER is accomplished by restricted processing of the activating ligand, Spitz. Processing is confined to the cell row posterior to the Engrailed domain by the restricted expression of Rhomboid. These cells also express the inhibitory ligand Argos, which...

... cells covering the oocyte expressed λtop. The expression of genes known to respond to top/Egfr activation, argos ( aos ), kekkon1 ( kek 1 ) and rhomboid ( rho ), was also expanded in the presence of the λtop construct. When λtop was expressed in all the follicle cells covering the oocyte, kek 1...

... for correspondence (e-mail: jacobsr@mcmaster.ca ) 19 07 1997 © 1997 by Company of Biologists 1997 Drosophila glia EGF Receptor rhomboid spitz argos apoptosis Generation of the intricate cytoarchitecture of a mature nervous system depends in part upon the initial...

... embryos, neuroectodermal genes, such as single-minded and rhomboid , are derepressed while ventral invagination proceeds normally. However, the differentiation of these invaginated cells into mesodermal lineage is disrupted. The results suggest that the establishment of mesodermal cell fate requires...

... expression in the tracheal cells of thick veins ( tkv ) and rhomboid ( rho ), two genes whose mutations disrupt only particular branches of the tracheal system. Indeed, we show that expression in the tracheal cells of an activated form of tkv, the putative decapentaplegic (dpp) receptor, is able to induce...

... in many studies, the determination machinery of Ch organ precursor cells (COPs) remains largely unresolved. Here we report that the rhomboid ( rho ) gene and the activity of the Drosophila EGF receptor (DER) signaling pathway are necessary to induce specifically three of the eight COPs in an embryonic...

... that the anterior edge of the salm expression domain abuts a narrow stripe of rhomboid ( rho )-expressing cells corresponding to the L2 longitudinal vein primordium. hh mis-expression along the anterior wing margin induces a surrounding domain of salm expression, the anterior edge of which abuts a displaced rho L2...

... ectoderm. This work shows that the midline provides the site for Spitz expression and processing. The Rhomboid and Star proteins are also expressed and required in the midline. The ectodermal defects of spitz, rho or Star mutant embryos could be rescued by inducing the expression of the respective normal...