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Keywords: Rhombic lip
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Journal Articles

Cerebellar granular neuron progenitors exit their germinative niche via BarH-like1 activity mediated partly by inhibition of T-cell factor

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Johnny Bou-Rouphael, Mohamed Doulazmi, Alexis Eschstruth, Asna Abdou, Béatrice C. Durand
Journal: Development
Development (2024) 151 (13): dev202234.
https://doi.org/10.1242/dev.202234
Published: 10 July 2024
...Johnny Bou-Rouphael; Mohamed Doulazmi; Alexis Eschstruth; Asna Abdou; Béatrice C. Durand ABSTRACT Cerebellar granule neuron progenitors (GNPs) originate from the upper rhombic lip (URL), a germinative niche in which developmental defects produce human diseases. T-cell factor (TCF) responsiveness...
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Includes: Supplementary data
Journal Articles

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway

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Roi Gazit, Valery Krizhanovsky, Nissim Ben-Arie
Journal: Development
Development (2004) 131 (4): 903–913.
https://doi.org/10.1242/dev.00982
Published: 15 February 2004
.... To delineate the effects of Math1 on CGC differentiation, we generated and studied primary cultures of CGC progenitors from Math1 / lacZ knockout mice. Rhombic lip precursors appeared properly positioned, expressed CGC-specific markers, and maintained Math1 promoter activity in vivo and in vitro,suggesting...
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Journal Articles

Role of Pax6 in development of the cerebellar system

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Dieter Engelkamp, Penny Rashbass, Anne Seawright, Veronica van Heyningen
Journal: Development
Development (1999) 126 (16): 3585–3596.
https://doi.org/10.1242/dev.126.16.3585
Published: 15 August 1999
...Dieter Engelkamp; Penny Rashbass; Anne Seawright; Veronica van Heyningen Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6 , a key...
View articletitled, Role of Pax6 in development of the cerebellar system
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